Altered sulfite oxidase expression contributes to AMP-activated protein kinase-dependent mitochondrial dysfunction and metabolic dysregulation in polycystic ovary syndrome - PubMed
5 hours ago
- #PCOS
- #Metabolic Regulation
- #Mitochondrial Dysfunction
- Reduced sulfite oxidase (SUOX) expression in PCOS contributes to AMPK pathway suppression.
- SUOX deficiency leads to mitochondrial dysfunction, impaired autophagy, and increased lipid synthesis in ovarian cells.
- Restoration of SUOX or AMPK activation reverses these pathological changes in cellular and mouse models.
- The SUOX-AMPK axis is implicated as a key molecular target for potential PCOS diagnosis and treatment.