Butyrate Regulates the Blood-Brain Barrier Transport and Intraendothelial Accumulation of Alzheimer's Disease Amyloid-Beta Peptides - PubMed
3 hours ago
- #Blood-brain barrier
- #Alzheimer's disease
- #Butyrate
- Butyrate reduces Aβ42 accumulation in brain endothelial cells by activating insulin signaling pathways (AKT and ERK).
- The study shows that butyrate restores P-gp expression and claudin-5 tight junction protein levels, improving blood-brain barrier integrity.
- Inhibiting AKT or ERK pathways reversed butyrate's protective effects on Aβ42 accumulation, while mTOR or p38 inhibition had no significant effect.
- In vivo experiments with butyrate-producing bacteria in mice supported the upregulation of TIMP-2, indicating extracellular matrix stabilization.
- The findings suggest butyrate as a potential therapeutic agent for Alzheimer's disease by modulating BBB dysfunction and reducing amyloid-beta accumulation.