Safety of BNT162b2 COVID-19 Vaccine in Pregnancy: A Systematic Review - PubMed
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- No increased risk observed for miscarriage, congenital anomalies, preterm birth, hypertensive disorders, small for gestational age, low birth weight, or neonatal death after BNT162b2 vaccination in over 450,000 pregnant women.
- Cumulative evidence demonstrates a reassuring safety profile for BNT162b2 COVID-19 vaccination with no indication of increased pregnancy-related or neonatal risk, supporting vaccination as an effective and safe means to reduce preventable maternal morbidity.
- Trimester-specific data, particularly for first-trimester exposure, were limited, and evidence is mainly observational and heterogeneous with limited precision for rare outcomes, but results align with international registry and surveillance findings.