Abdominal adiposity and Alzheimer's disease imaging markers across sex and race at midlife - PubMed
5 hours ago
- #Alzheimer's disease
- #neuroimaging
- #obesity
- Midlife obesity is a modifiable risk factor for dementia and Alzheimer's disease, but BMI alone doesn't fully capture obesity-related risks.
- In a study of 97 cognitively normal midlife individuals, visceral adipose tissue volume correlated with amyloid PET burden, especially in females and Whites.
- Higher visceral fat relative to subcutaneous fat (VAT/SAT ratio) was linked to higher tau pathology after adjusting for factors like age and amyloid.
- Lower HDL cholesterol was associated with amyloid burden regardless of sex and race, but did not mediate the visceral fat-amyloid relationship.
- Findings suggest visceral fat may be a key marker for Alzheimer's disease pathology at midlife, independent of BMI.