Activation of sarco/endoplasmic reticulum Ca²⁺-ATPase 2 (SERCA2) reduces brain injury and improves cognitive function following ischemic stroke - PubMed
4 hours ago
- #SERCA2 activation
- #neuroprotection
- #ischemic stroke
- Activation of SERCA2 pump via CDN1163 reduces brain injury and improves cognitive function post-ischemic stroke in mice.
- CDN1163 treatment improved Ca²⁺ handling, reduced infarct volume, preserved blood-brain barrier, and suppressed oxidative stress and inflammation.
- Mechanistically, CDN1163 inhibited NLRP3 inflammasome, decreased apoptosis markers, and enhanced oxidative phosphorylation protein expression.
- The study highlights SERCA2 activation as a therapeutic strategy to restore calcium homeostasis and attenuate neuroinflammation in stroke.