Molecular interplay between Non-coding RNAs and BDNF in Neurodegenerative Disorders: a systematic review - PubMed
5 hours ago
- #Non-coding RNAs
- #Neurodegenerative Disorders
- #BDNF Regulation
- BDNF is crucial for nervous system development, maintenance, and neurogenesis, with aberrant levels linked to neurodegenerative disorders like Alzheimer's, Parkinson's, ALS, Huntington's, and Multiple sclerosis.
- Non-coding RNAs (ncRNAs), including miRNAs and lncRNAs, regulate gene expression and are implicated in neurodegenerative disease processes, serving as potential biomarkers and therapeutic targets.
- This systematic review synthesizes literature on ncRNAs that modulate BDNF expression in neurodegeneration, focusing on their diagnostic and prognostic utility and exploring BDNF-associated miRNA-targeted therapies.
- Evidence for ncRNA-mediated post-transcriptional regulation of BDNF in neurodegeneration is currently limited, highlighting a gap in empirical research.