A Mitoxyperilysis-Related Single-Cell and Machine-Learning Framework Defines an Immune-Cold Melanoma Phenotype and a Robust Prognostic Signature - PubMed
3 hours ago
- #immune-cold melanoma
- #prognostic signature
- #mitoxyperilysis
- A mitoxyperilysis-related score (MRS) was analyzed from single-cell RNA-seq data in melanoma.
- MRS-high tumors showed increased predicted cell-cell communication compared to MRS-low tumors.
- A machine-learning signature using gradient boosting machine (GBM) was developed from MRS-correlated genes.
- This signature reliably stratified patient survival and was validated across multiple external cohorts.
- High riskScore associated with immune-cold tumor microenvironment, reduced immune signals, and higher tumor purity.
- GPR143 identified as a model gene; its knockdown suppressed melanoma cell colony formation.