Plasma ApoE proteotyping for ApoE ε4 stratification in the anti-amyloid therapies era - PubMed
3 hours ago
- #Biomarkers
- #Alzheimer's disease
- #Personalized medicine
- Automated plasma ApoE proteotyping, using the ApoE4/PanApoE ratio, accurately stratified ApoE ε4 carrier status with an AUC of 1.00.
- The study included 110 patients with cognitive impairment and found excellent separation between ε4 non-carriers, heterozygotes, and homozygotes.
- The approach offers advantages over genotyping, such as lower cost and faster turnaround, but requires validation in larger, independent cohorts.