MRGPRX2 as a novel therapeutic target in headache - PubMed
5 hours ago
- #neuroimmune
- #migraine
- #MRGPRX2
- MRGPRX2/B2 is identified as a novel therapeutic target for migraine.
- Mast cells in the meninges interact with sensory neurons via MRGPRX2/B2, contributing to neurogenic inflammation and pain.
- Neuropeptides like substance P and PACAP activate MRGPRX2/B2, leading to mast cell degranulation and neuronal sensitization.
- Targeting MRGPRX2/B2 may offer new treatment strategies for migraine by modulating neuroimmune interactions.