USP21 functions as an oncogenic regulator of the Mdm2-p53 axis in colorectal cancer - PubMed
3 hours ago
- #colorectal cancer
- #Mdm2-p53 axis
- #USP21
- USP21 interacts with and stabilizes Mdm2 independent of its deubiquitinase activity.
- USP21 acts as a scaffold to enhance USP7-Mdm2 interaction, increasing Mdm2 stability and promoting p53 degradation.
- USP21-mediated p53 suppression accelerates colorectal cancer progression and correlates with poor survival in wild-type p53 tumors.
- USP21 is upregulated in colorectal cancer tissues and functions as an oncogenic regulator of the Mdm2-p53 axis.