Position statement of the spanish working group on crohn's disease and ulcerative colitis (geteccu) on the diagnosis and management of acute severe ulcerative colitis - PubMed
5 hours ago
- #GETECCU Guidelines
- #Acute Severe Ulcerative Colitis
- #Medical Management
- Acute severe ulcerative colitis (ASUC) is a medical emergency needing hospitalization and urgent, structured care.
- Diagnosis should be rapid and standardized, focusing on excluding infections like Clostridioides difficile and cytomegalovirus.
- First-line treatment is intravenous corticosteroids, with response evaluated at 72 hours using validated criteria.
- For steroid-refractory cases, infliximab and cyclosporine are equally effective rescue options; choice depends on patient specifics.
- JAK inhibitors are emerging as a potential therapy, though evidence is still limited.
- Supportive measures are critical, including nutrition optimization, thromboprophylaxis, and continuous monitoring.
- Early surgical assessment is essential for patients unresponsive to medical therapy or with complications.
- Management requires a multidisciplinary approach in specialized centers to improve outcomes.