GPR35 modulates NaV1.9 gating and sensory neuron excitability - PubMed
5 hours ago
- #GPR35
- #NaV1.9
- #sensory neurons
- GPR35 modulates NaV1.9 function in sensory neurons, establishing a new receptor-channel signaling axis.
- Activation of GPR35 with cromolyn potentiates NaV1.9 currents, accelerates gating, and increases neuronal excitability.
- GPR35-dependent effects on NaV1.9 involve cGMP-associated signaling, as shown by zaprinast and sildenafil.
- Under inflammatory conditions, GPR35 activation partially attenuates NaV1.9 potentiation but does not restore normal excitability.
- This study identifies GPR35 as a regulator of NaV1.9, linking GPCR activation to sensory neuron excitability modulation.