Targeting HIF-2α in colorectal cancer reveals a cholesterol biosynthesis-dependent ferroptotic vulnerability - PubMed
3 months ago
- #HIF-2α
- #colorectal cancer
- #ferroptosis
- Targeting HIF-2α in colorectal cancer reveals a cholesterol biosynthesis-dependent ferroptotic vulnerability.
- Combined HIF-2α inhibition and cholesterol biosynthesis inhibition using statins enhances ferroptosis, offering a therapeutic strategy.
- Disclosure: CAL served as a consultant for several pharmaceutical companies and holds patents related to cancer metabolic pathways.
- Other authors declare no competing interests.
- References highlight the role of HIF-2α in colorectal cancer progression, iron homeostasis, oxidative cell death, and tumor growth.