Clinicopathologic characterization of renal tumors with Folliculin (FLCN) biallelic inactivation - PubMed
3 hours ago
- #Birt-Hogg-Dubé syndrome
- #FLCN biallelic inactivation
- #renal tumor characterization
- Study characterizes renal tumors with molecularly confirmed FLCN biallelic inactivation.
- Most tumors show conventional histology with eosinophilic and clear cell mosaic.
- Two cases display non-conventional histology linked to advanced stage or metastasis.
- Immunohistochemistry reveals consistent GPNMB expression and mosaic staining patterns.
- Findings support recognizing FLCN-driven tumors as a distinct molecular entity.