IFITM1 differentially regulates antibacterial immunity and immunopathology but is dispensable for antiparasitic responses - PubMed
5 hours ago
- #IFITM1
- #Bacterial Immunity
- #Immunopathology
- IFITM1 is upregulated in macrophages and PBMCs during active TB and decreases after treatment.
- IFITM1 deficiency in mice leads to lower bacterial loads and reduced lung pathology during chronic Mtb infection.
- IFITM1-/- macrophages restrict intracellular growth of Mtb strains and alter proinflammatory cytokine production.
- IFITM1-/- mice infected with Mtb show increased lung cell death and higher mortality.
- In Listeria infection, IFITM1-/- mice have reduced early bacterial burdens but increased liver pathology and mortality.
- IFITM1-/- macrophages limit intracellular Listeria growth and show increased necrosis.
- IFITM1 does not affect disease progression or parasitic loads in Leishmania major infection.
- IFITM1 exacerbates pathology in TB and listeriosis by balancing inflammation and bacterial control, but is dispensable for antiparasitic responses.