FERPIR promotes cardiomyocyte survival and attenuates cardiac remodeling after myocardial infarction - PubMed
3 hours ago
- #piRNA
- #Ferroptosis
- #Cardiac Remodeling
- FERPIR is a ferroptosis-related piRNA that protects the heart after myocardial infarction.
- It works by targeting HNRNPA2B1 to stabilize it, which then reduces Fis1 mRNA stability, inhibiting mitochondrial fission and ferroptosis.
- Overexpression of FERPIR decreases cardiac injury, remodeling, and ferroptosis in models of ischemia/reperfusion and hypoxia/reoxygenation.
- This pathway offers potential therapeutic targets for treating heart injury caused by ferroptosis.