Acetylated mitochondrial MDH2 regulates CTR2 transcription to induce cuproptosis during Escherichia coli infection - PubMed
3 hours ago
- #cuproptosis
- #E. coli infection
- #MDH2 acetylation
- E. coli infection upregulates copper transporter CTR2 to disrupt copper homeostasis, inducing cuproptosis and driving infectious pathology.
- Lipopolysaccharide (LPS) activates cuproptosis via the gut-LPS-liver axis during infection.
- Mitochondrial MDH2, through acetylation-dependent nuclear translocation, acts as a transcriptional regulator to trigger CTR2 expression and metabolic reprogramming.
- Inhibiting cuproptosis reduces liver damage from infection, highlighting its importance in pathogen-host interactions.
- The findings suggest therapeutic potential in targeting metal-dependent cell death pathways for E. coli infections.