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Neural Stem Cell-Derived Exosomes-Transmitted miR-31-5p Promote Functional Recovery of Spinal Cord Injury by Shifting Astrocytes A1/A2 Polarization - PubMed
9 days ago
- Neural stem cell-derived exosomes enhance motor recovery after spinal cord injury by shifting astrocytes from harmful A1 to protective A2 phenotypes.
- miR-31-5p is the most enriched miRNA in these exosomes and targets interleukin-34 (Il34), downregulating the Il34/Stat3 signaling pathway in astrocytes.
- Rescue experiments confirm that miR-31-5p-mediated inhibition of Il34/Stat3 promotes astrocyte phenotypic change and neurorepair, suggesting therapeutic potential for SCI.
Two-Year Outcomes of Less Invasive Surfactant Administration Among Preterm Neonates: A Secondary Analysis of a Randomized Clinical Trial - PubMed
9 days ago
- A secondary analysis of a randomized trial examined two-year outcomes in preterm neonates receiving less invasive surfactant administration (LISA) plus early caffeine, compared to CPAP alone.
- The primary outcome, death or moderate to severe neurodevelopmental impairment (NDI) at a corrected age of 2 years, did not show a significant reduction with LISA (23.0% vs. 32.9%, OR 1.56, p=0.22).
- On developmental screening (ASQ-3), LISA infants had a higher likelihood of fine motor scores in the reference range, but no significant differences in typical development rates or scores indicating possible delay.
- No significant differences were found in pulmonary outcomes, including bronchodilator use, corticosteroid use, or post-discharge respiratory hospitalizations between groups.
- The study concluded that early caffeine plus LISA did not reduce death or moderate to severe NDI, but may benefit fine motor development as measured by ASQ-3.
The impact of antigen presentation on BBB disruption and neuroinflammation - PubMed
9 days ago
- Blood brain barrier (BBB) disruption is a key complication in various neurological diseases, linking conditions like cerebral malaria, COVID-19, and Parkinson's disease.
- Neuroinflammation and immune cell infiltration both drive and result from BBB disruption, with T cell responses interacting with the neurovascular unit (NVU) in preclinical models.
- MHC class I and class II molecules on NVU cells regulate T cell entry, retention, and barrier disruption in neuroinflammatory diseases.
- Specific HLA genes are associated with neurological diseases featuring neuroinflammation and BBB disruption, highlighting the role of antigen presentation in neuropathology.
A neuropeptide regulates cell non-autonomous protein homeostasis - PubMed
9 days ago
- Glial UPRER activation in C. elegans increases specific neuropeptides, including FLP-17.
- FLP-17, acting partially through EGL-6 receptor, induces cell non-autonomous UPRER and stress resistance.
- XBP-1 and PERK are both required for maximal FLP-17-induced UPRER, but only XBP-1 is essential for ER stress resistance.
- The study identifies FLP-17 as a key mediator coordinating organismal proteostasis via a sensory-metabolic circuit.
Mortality impact of long-term home non-invasive ventilation in COPD patients with versus without obstructive sleep apnea - PubMed
9 days ago
- Overlap syndrome (COPD plus OSA) patients on home NIV have a 33% lower mortality rate compared to COPD-only patients.
- Transition probabilities from severe exacerbation to death and from non-exacerbation to death were lower in overlap syndrome (10% and 5%) than in COPD without OSA (22% and 18%).
- Overlap syndrome patients also showed a higher rate of recovery from severe exacerbation to non-exacerbation after NIV initiation.
- The study highlights the importance of screening for OSA in COPD patients, as those with overlap syndrome benefit more from long-term home NIV therapy.
Spirocyclic β-lactone secondary metabolites modulate spliceosome function - PubMed
9 days ago
- Spirocyclic β-lactones (SβLs) are natural products with potent cytotoxicity and an unknown mechanism, produced by actinomycetota.
- Study isolated SβLs from Streptomyces platensis, including a new variant, linking them to the oxazolomycin D (OxD) family via a cryptic gene cluster.
- SβLs have two pharmacophores: a polyketide component for target engagement and a β-lactone warhead for cytotoxicity.
- OxD treatment interacts with spliceosome proteins, validated by alternative splicing changes, suggesting therapeutic potential in cancers with aberrant splicing.
Neural circuits for decision-making based on pineal photoreception in zebrafish - PubMed
9 days ago
- Zebrafish pineal organs have photosensitive cells using parapinopsin 1 (PP1), a bistable opsin, for chromatic responses to UV and visible light.
- Pineal ganglion cells show chromatic responses reliant on PP1, as evidenced by calcium imaging and reduced responses in PP1-deficient fish.
- The tegmentum in the brain receives pineal color information and also integrates indirect retinal input, influencing vertical movement decisions.
- PP1-deficient and tegmentum neuron-ablated fish display impaired vertical movements in response to wavelength changes, indicating the circuit's role in decision-making.
- The study provides insights into neural circuits combining pineal and retinal light information, and how PP1-based color processing affects behavior.
Recurrent aquaporin 4-immunoglobulin G-positive neuromyelitis optica spectrum disorder in a patient with long-standing rheumatoid arthritis: A case report - PubMed
9 days ago
- Aquaporin 4-IgG positive neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune condition affecting optic nerves and spinal cord.
- Co-occurrence of NMOSD and rheumatoid arthritis (RA) is rare, with only 15 cases reported globally.
- A 34-year-old woman with long-standing RA developed relapsing NMOSD, highlighting risk of misdiagnosis as stroke in autoimmune patients with neurological symptoms.
- The report examines shared immunopathological mechanisms and suggests integrated treatment strategies for managing both disorders.
- It emphasizes the need for prompt brain/spinal cord MRI and aquaporin 4-IgG testing in RA patients with optic neuritis, a gap in current guidelines.
Effects of intravenous furosemide plus small-volume hypertonic saline solutions on inflammatory, remodelling markers and epigenetics signatures of patients with congestive acute decompensated heart fa
9 days ago
- The study compared treatment with intravenous furosemide plus small-volume hypertonic saline solution (HSS) versus furosemide alone in patients with acute decompensated heart failure (ADHF) due to reduced ejection fraction.
- Patients receiving furosemide plus HSS showed higher absolute delta values for IL-6, hsTnT, NT-proBNP, and galectin-3 at post-treatment evaluation.
- After saline load, the furosemide plus HSS group had significantly lower increases in serum concentrations of IL-6, hsTnT, sST2, galectin-3, and NT-proBNP compared to furosemide alone.
- Expression of miR181b decreased more significantly in patients treated with furosemide plus HSS than in those treated with furosemide alone.
- The findings suggest that furosemide plus HSS treatment reduces inflammatory and remodeling markers and modulates miRNA expression in ADHF patients.
Vitamin E alleviates experimental autoimmune prostatitis by inhibiting the EGFR/MAPK pathway to reduce M1 macrophage polarization - PubMed
9 days ago
- Vitamin E reduces symptoms in a mouse model of experimental autoimmune prostatitis (EAP) and lowers pro-inflammatory cytokines like IL-1β, IL-6, and TNF-α.
- Mechanistically, Vitamin E inhibits macrophage M1 polarization by blocking the EGFR/MAPK pathway, with direct binding to EGFR confirmed via molecular docking and SPR.
- The study suggests Vitamin E as a potential treatment for chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) by targeting inflammation through EGFR/MAPK suppression.
Mitochondrial kinase CMPK2 in immune homeostasis and disease: from metabolic regulation to inflammatory signaling - PubMed
9 days ago
- CMPK2 is a mitochondrial enzyme vital for nucleotide metabolism, immune regulation, and disease processes.
- It maintains mitochondrial DNA integrity and energy metabolism, linking mitochondrial stress to inflammation via pathways like NLRP3 and cGAS-STING.
- Upregulated during viral infections such as SARS-CoV-2 and Zika, CMPK2 restricts virus replication and boosts antiviral defenses.
- CMPK2 dysregulation is implicated in diseases like systemic lupus erythematosus and neuroblastoma, highlighting its potential as a diagnostic biomarker and therapeutic target.
- This review establishes CMPK2 as a key node connecting mitochondrial metabolism, immune responses, and disease mechanisms, calling for further research into its functions and clinical applications.
Higher ultra-processed food consumption is associated with higher likelihood of paediatric-onset multiple sclerosis - PubMed
9 days ago
- Higher consumption of ultra-processed foods is associated with increased odds of paediatric-onset multiple sclerosis (PoMS).
- Each 10% increase in ultra-processed food consumption raises the odds of PoMS by 35%.
- Individuals in the highest tertile of ultra-processed food consumption have over five times higher odds of PoMS compared to the lowest tertile.
- The study analyzed dietary data from PoMS cases and unaffected controls using the Nova food processing classification.
- Findings highlight a link between ultra-processed foods and inflammatory diseases like MS in children.
- The authors call for more comprehensive longitudinal dietary data to further understand this relationship.
Association between the estimated glucose disposal rate and new-onset chronic obstructive pulmonary disease in United States adults - PubMed
9 days ago
- Study investigates the link between estimated glucose disposal rate (eGDR) and new-onset chronic obstructive pulmonary disease (COPD) in U.S. adults.
- Higher eGDR, indicating better insulin sensitivity, is associated with lower odds of COPD, with the relationship showing a non-linear pattern.
- An interaction with hypertension is noted: the inverse association is significant in individuals without hypertension but not in those with hypertension.
- eGDR demonstrates strong discriminatory power for COPD (AUC 0.82) and outperforms HOMA-IR in unadjusted models, with an optimal threshold of ~8.2 mg/kg/min.
Alisol B as a novel inhibitor of TβRs suppresses the growth and metastasis of non-small cell lung cancer by inhibiting TGF-β-induced epithelial-mesenchymal transition - PubMed
9 days ago
- Alisol B (ALB) inhibits TGF-β1-induced proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT) in lung adenocarcinoma cells.
- ALB directly binds to ATP-binding sites of TGF-β receptors (TGFβR1 and TGFβR2), promoting TGFβR2 degradation and suppressing downstream signaling pathways.
- In vivo studies show ALB suppresses tumor growth and lung metastasis in mouse models of non-small cell lung cancer (NSCLC).
Cerebral small vessel disease imaging markers and disease severity in moyamoya disease: Insights from magnetic resonance imaging analysis - PubMed
9 days ago
- Cerebral small vessel disease (CSVD) imaging markers were significantly higher in moyamoya disease (MMD) patients compared to healthy controls, including asymptomatic cases.
- Factors independently associated with severe CSVD burden in MMD include older age, hemorrhage, infarction, advanced Suzuki stage (≥4), and high platelet-lymphocyte ratio.
- The summary CSVD score strongly correlates with MMD disease severity, as shown by a high area under the curve (AUC = 0.809).
- CSVD imaging markers are effective indicators for assessing MMD severity and progression, especially in older patients and those with ischemic symptoms.
Revitalizing mitochondrial quality control: targeting mitochondria-derived vesicles in Parkinson's disease - PubMed
9 days ago
- Parkinson's disease (PD) is characterized by loss of dopaminergic neurons and lacks disease-modifying therapies.
- Impaired mitochondrial quality control (MQC), including mechanisms like biogenesis, dynamics, mitophagy, and mitochondria-derived vesicles (MDVs), is a central driver of PD pathogenesis.
- MDVs are small vesicles that transport damaged mitochondrial components to lysosomes for degradation, offering a rapid, localized alternative to mitophagy.
- MDVs also function in inter-organelle signaling and intercellular communication, influencing neuronal homeostasis.
- Disruption of MDV processes contributes to mitochondrial dysfunction and neurodegeneration in PD.
- Targeting MDV pathways may provide novel diagnostic and therapeutic strategies to modify PD progression.
Dual-chemokine-armed oncolytic Senecavirus A co-recruits cDC1 and CXCR3+ T cells to convert 'cold' melanoma and drive durable regression - PubMed
9 days ago
- Engineered recombinant Senecavirus A (SVA) to co-express chemokines CXCL11 and vXCL1 for synergistic immune cell recruitment.
- Deletion of signal peptides improved genetic stability and intratumoral payload retention without affecting viral fitness.
- CXCL11 monotherapy enhanced tumor control, prolonged survival, and suggested protection against tumor rechallenge in mouse models.
- Combination of CXCL11 and vXCL1 increased dendritic cell activation, CD8+ T-cell infiltration, and M1 macrophage polarization.
- The dual-chemokine approach led to deeper and more durable tumor regression in 'cold' melanoma models.
Effects of Kegel Exercises on Women With Urinary Incontinence: A Systematic Review and Meta-Analysis - PubMed
9 days ago
- Kegel exercises showed no significant differences in Incontinence Questionnaire-Short Form scores, PAD test results, or pelvic floor muscle strength when analyzed alone.
- Significant improvements in urinary incontinence outcomes were observed when Kegel exercises were combined with other treatments.
- The systematic review included 11 randomized controlled trials involving 819 women, with evidence quality assessed using Cochrane Risk of Bias 2 tool.
- Overall evidence for the effects of Kegel exercises on urinary incontinence is limited, suggesting need for further studies tailored to different health profiles.
Rates of Retreatment after Transvenous Embolization of CSF-Venous Fistulas in Spontaneous Intracranial Hypotension - PubMed
9 days ago
- Approximately 23% of patients with cerebrospinal fluid-venous fistulas (CVF) treated with transvenous embolization (TVE) required retreatment.
- Most retreatment patients (74%) experienced persistent or recurrent symptoms within 3 months after the initial TVE.
- About one-third of retreatments were due to CVF recurrence at the same site and level, one-third adjacent to the original site, and one-third remote from the initial fistula.
Perspective: Depression in Persons with Parkinson's Disease - PubMed
9 days ago
- Depression in Parkinson's disease is common, affecting approximately 17% with major depressive disorder and over one-third with significant symptoms.
- Diagnosis is complicated by overlapping symptoms with PD; an inclusive diagnostic approach and PD-validated rating scales are recommended.
- Treatment follows general algorithms, including SSRIs, SNRIs, TCAs, and psychotherapy like cognitive behavioral therapy, with adjustments for PD-related vulnerabilities.
- Access to care is limited by a shortage of mental health specialists with PD expertise.
- PD serves as a model for studying mood regulation neurobiology, involving dopaminergic, serotonergic, and noradrenergic systems.
- Emerging methods such as deep brain stimulation, ecological momentary assessment, neuroimaging, and machine learning enhance understanding of emotional processing in PD.
- Future research aims to refine diagnostics, optimize therapies, and deepen insights into affective dysregulation in PD.

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Bilingual

Neural Stem Cell-Derived Exosomes-Transmitted miR-31-5p Promote Functional Recovery of Spinal Cord Injury by Shifting Astrocytes A1/A2 Polarization - PubMed
9 days ago
- Neural stem cell-derived exosomes enhance motor recovery after spinal cord injury by shifting astrocytes from harmful A1 to protective A2 phenotypes.
- miR-31-5p is the most enriched miRNA in these exosomes and targets interleukin-34 (Il34), downregulating the Il34/Stat3 signaling pathway in astrocytes.
- Rescue experiments confirm that miR-31-5p-mediated inhibition of Il34/Stat3 promotes astrocyte phenotypic change and neurorepair, suggesting therapeutic potential for SCI.
Two-Year Outcomes of Less Invasive Surfactant Administration Among Preterm Neonates: A Secondary Analysis of a Randomized Clinical Trial - PubMed
9 days ago
- A secondary analysis of a randomized trial examined two-year outcomes in preterm neonates receiving less invasive surfactant administration (LISA) plus early caffeine, compared to CPAP alone.
- The primary outcome, death or moderate to severe neurodevelopmental impairment (NDI) at a corrected age of 2 years, did not show a significant reduction with LISA (23.0% vs. 32.9%, OR 1.56, p=0.22).
- On developmental screening (ASQ-3), LISA infants had a higher likelihood of fine motor scores in the reference range, but no significant differences in typical development rates or scores indicating possible delay.
- No significant differences were found in pulmonary outcomes, including bronchodilator use, corticosteroid use, or post-discharge respiratory hospitalizations between groups.
- The study concluded that early caffeine plus LISA did not reduce death or moderate to severe NDI, but may benefit fine motor development as measured by ASQ-3.
The impact of antigen presentation on BBB disruption and neuroinflammation - PubMed
9 days ago
- Blood brain barrier (BBB) disruption is a key complication in various neurological diseases, linking conditions like cerebral malaria, COVID-19, and Parkinson's disease.
- Neuroinflammation and immune cell infiltration both drive and result from BBB disruption, with T cell responses interacting with the neurovascular unit (NVU) in preclinical models.
- MHC class I and class II molecules on NVU cells regulate T cell entry, retention, and barrier disruption in neuroinflammatory diseases.
- Specific HLA genes are associated with neurological diseases featuring neuroinflammation and BBB disruption, highlighting the role of antigen presentation in neuropathology.
A neuropeptide regulates cell non-autonomous protein homeostasis - PubMed
9 days ago
- Glial UPRER activation in C. elegans increases specific neuropeptides, including FLP-17.
- FLP-17, acting partially through EGL-6 receptor, induces cell non-autonomous UPRER and stress resistance.
- XBP-1 and PERK are both required for maximal FLP-17-induced UPRER, but only XBP-1 is essential for ER stress resistance.
- The study identifies FLP-17 as a key mediator coordinating organismal proteostasis via a sensory-metabolic circuit.
Mortality impact of long-term home non-invasive ventilation in COPD patients with versus without obstructive sleep apnea - PubMed
9 days ago
- Overlap syndrome (COPD plus OSA) patients on home NIV have a 33% lower mortality rate compared to COPD-only patients.
- Transition probabilities from severe exacerbation to death and from non-exacerbation to death were lower in overlap syndrome (10% and 5%) than in COPD without OSA (22% and 18%).
- Overlap syndrome patients also showed a higher rate of recovery from severe exacerbation to non-exacerbation after NIV initiation.
- The study highlights the importance of screening for OSA in COPD patients, as those with overlap syndrome benefit more from long-term home NIV therapy.
Spirocyclic β-lactone secondary metabolites modulate spliceosome function - PubMed
9 days ago
- Spirocyclic β-lactones (SβLs) are natural products with potent cytotoxicity and an unknown mechanism, produced by actinomycetota.
- Study isolated SβLs from Streptomyces platensis, including a new variant, linking them to the oxazolomycin D (OxD) family via a cryptic gene cluster.
- SβLs have two pharmacophores: a polyketide component for target engagement and a β-lactone warhead for cytotoxicity.
- OxD treatment interacts with spliceosome proteins, validated by alternative splicing changes, suggesting therapeutic potential in cancers with aberrant splicing.
Neural circuits for decision-making based on pineal photoreception in zebrafish - PubMed
9 days ago
- Zebrafish pineal organs have photosensitive cells using parapinopsin 1 (PP1), a bistable opsin, for chromatic responses to UV and visible light.
- Pineal ganglion cells show chromatic responses reliant on PP1, as evidenced by calcium imaging and reduced responses in PP1-deficient fish.
- The tegmentum in the brain receives pineal color information and also integrates indirect retinal input, influencing vertical movement decisions.
- PP1-deficient and tegmentum neuron-ablated fish display impaired vertical movements in response to wavelength changes, indicating the circuit's role in decision-making.
- The study provides insights into neural circuits combining pineal and retinal light information, and how PP1-based color processing affects behavior.
Recurrent aquaporin 4-immunoglobulin G-positive neuromyelitis optica spectrum disorder in a patient with long-standing rheumatoid arthritis: A case report - PubMed
9 days ago
- Aquaporin 4-IgG positive neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune condition affecting optic nerves and spinal cord.
- Co-occurrence of NMOSD and rheumatoid arthritis (RA) is rare, with only 15 cases reported globally.
- A 34-year-old woman with long-standing RA developed relapsing NMOSD, highlighting risk of misdiagnosis as stroke in autoimmune patients with neurological symptoms.
- The report examines shared immunopathological mechanisms and suggests integrated treatment strategies for managing both disorders.
- It emphasizes the need for prompt brain/spinal cord MRI and aquaporin 4-IgG testing in RA patients with optic neuritis, a gap in current guidelines.
Effects of intravenous furosemide plus small-volume hypertonic saline solutions on inflammatory, remodelling markers and epigenetics signatures of patients with congestive acute decompensated heart fa
9 days ago
- The study compared treatment with intravenous furosemide plus small-volume hypertonic saline solution (HSS) versus furosemide alone in patients with acute decompensated heart failure (ADHF) due to reduced ejection fraction.
- Patients receiving furosemide plus HSS showed higher absolute delta values for IL-6, hsTnT, NT-proBNP, and galectin-3 at post-treatment evaluation.
- After saline load, the furosemide plus HSS group had significantly lower increases in serum concentrations of IL-6, hsTnT, sST2, galectin-3, and NT-proBNP compared to furosemide alone.
- Expression of miR181b decreased more significantly in patients treated with furosemide plus HSS than in those treated with furosemide alone.
- The findings suggest that furosemide plus HSS treatment reduces inflammatory and remodeling markers and modulates miRNA expression in ADHF patients.
Vitamin E alleviates experimental autoimmune prostatitis by inhibiting the EGFR/MAPK pathway to reduce M1 macrophage polarization - PubMed
9 days ago
- Vitamin E reduces symptoms in a mouse model of experimental autoimmune prostatitis (EAP) and lowers pro-inflammatory cytokines like IL-1β, IL-6, and TNF-α.
- Mechanistically, Vitamin E inhibits macrophage M1 polarization by blocking the EGFR/MAPK pathway, with direct binding to EGFR confirmed via molecular docking and SPR.
- The study suggests Vitamin E as a potential treatment for chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) by targeting inflammation through EGFR/MAPK suppression.
Mitochondrial kinase CMPK2 in immune homeostasis and disease: from metabolic regulation to inflammatory signaling - PubMed
9 days ago
- CMPK2 is a mitochondrial enzyme vital for nucleotide metabolism, immune regulation, and disease processes.
- It maintains mitochondrial DNA integrity and energy metabolism, linking mitochondrial stress to inflammation via pathways like NLRP3 and cGAS-STING.
- Upregulated during viral infections such as SARS-CoV-2 and Zika, CMPK2 restricts virus replication and boosts antiviral defenses.
- CMPK2 dysregulation is implicated in diseases like systemic lupus erythematosus and neuroblastoma, highlighting its potential as a diagnostic biomarker and therapeutic target.
- This review establishes CMPK2 as a key node connecting mitochondrial metabolism, immune responses, and disease mechanisms, calling for further research into its functions and clinical applications.
Higher ultra-processed food consumption is associated with higher likelihood of paediatric-onset multiple sclerosis - PubMed
9 days ago
- Higher consumption of ultra-processed foods is associated with increased odds of paediatric-onset multiple sclerosis (PoMS).
- Each 10% increase in ultra-processed food consumption raises the odds of PoMS by 35%.
- Individuals in the highest tertile of ultra-processed food consumption have over five times higher odds of PoMS compared to the lowest tertile.
- The study analyzed dietary data from PoMS cases and unaffected controls using the Nova food processing classification.
- Findings highlight a link between ultra-processed foods and inflammatory diseases like MS in children.
- The authors call for more comprehensive longitudinal dietary data to further understand this relationship.
Association between the estimated glucose disposal rate and new-onset chronic obstructive pulmonary disease in United States adults - PubMed
9 days ago
- Study investigates the link between estimated glucose disposal rate (eGDR) and new-onset chronic obstructive pulmonary disease (COPD) in U.S. adults.
- Higher eGDR, indicating better insulin sensitivity, is associated with lower odds of COPD, with the relationship showing a non-linear pattern.
- An interaction with hypertension is noted: the inverse association is significant in individuals without hypertension but not in those with hypertension.
- eGDR demonstrates strong discriminatory power for COPD (AUC 0.82) and outperforms HOMA-IR in unadjusted models, with an optimal threshold of ~8.2 mg/kg/min.
Alisol B as a novel inhibitor of TβRs suppresses the growth and metastasis of non-small cell lung cancer by inhibiting TGF-β-induced epithelial-mesenchymal transition - PubMed
9 days ago
- Alisol B (ALB) inhibits TGF-β1-induced proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT) in lung adenocarcinoma cells.
- ALB directly binds to ATP-binding sites of TGF-β receptors (TGFβR1 and TGFβR2), promoting TGFβR2 degradation and suppressing downstream signaling pathways.
- In vivo studies show ALB suppresses tumor growth and lung metastasis in mouse models of non-small cell lung cancer (NSCLC).
Cerebral small vessel disease imaging markers and disease severity in moyamoya disease: Insights from magnetic resonance imaging analysis - PubMed
9 days ago
- Cerebral small vessel disease (CSVD) imaging markers were significantly higher in moyamoya disease (MMD) patients compared to healthy controls, including asymptomatic cases.
- Factors independently associated with severe CSVD burden in MMD include older age, hemorrhage, infarction, advanced Suzuki stage (≥4), and high platelet-lymphocyte ratio.
- The summary CSVD score strongly correlates with MMD disease severity, as shown by a high area under the curve (AUC = 0.809).
- CSVD imaging markers are effective indicators for assessing MMD severity and progression, especially in older patients and those with ischemic symptoms.
Revitalizing mitochondrial quality control: targeting mitochondria-derived vesicles in Parkinson's disease - PubMed
9 days ago
- Parkinson's disease (PD) is characterized by loss of dopaminergic neurons and lacks disease-modifying therapies.
- Impaired mitochondrial quality control (MQC), including mechanisms like biogenesis, dynamics, mitophagy, and mitochondria-derived vesicles (MDVs), is a central driver of PD pathogenesis.
- MDVs are small vesicles that transport damaged mitochondrial components to lysosomes for degradation, offering a rapid, localized alternative to mitophagy.
- MDVs also function in inter-organelle signaling and intercellular communication, influencing neuronal homeostasis.
- Disruption of MDV processes contributes to mitochondrial dysfunction and neurodegeneration in PD.
- Targeting MDV pathways may provide novel diagnostic and therapeutic strategies to modify PD progression.
Dual-chemokine-armed oncolytic Senecavirus A co-recruits cDC1 and CXCR3+ T cells to convert 'cold' melanoma and drive durable regression - PubMed
9 days ago
- Engineered recombinant Senecavirus A (SVA) to co-express chemokines CXCL11 and vXCL1 for synergistic immune cell recruitment.
- Deletion of signal peptides improved genetic stability and intratumoral payload retention without affecting viral fitness.
- CXCL11 monotherapy enhanced tumor control, prolonged survival, and suggested protection against tumor rechallenge in mouse models.
- Combination of CXCL11 and vXCL1 increased dendritic cell activation, CD8+ T-cell infiltration, and M1 macrophage polarization.
- The dual-chemokine approach led to deeper and more durable tumor regression in 'cold' melanoma models.
Effects of Kegel Exercises on Women With Urinary Incontinence: A Systematic Review and Meta-Analysis - PubMed
9 days ago
- Kegel exercises showed no significant differences in Incontinence Questionnaire-Short Form scores, PAD test results, or pelvic floor muscle strength when analyzed alone.
- Significant improvements in urinary incontinence outcomes were observed when Kegel exercises were combined with other treatments.
- The systematic review included 11 randomized controlled trials involving 819 women, with evidence quality assessed using Cochrane Risk of Bias 2 tool.
- Overall evidence for the effects of Kegel exercises on urinary incontinence is limited, suggesting need for further studies tailored to different health profiles.
Rates of Retreatment after Transvenous Embolization of CSF-Venous Fistulas in Spontaneous Intracranial Hypotension - PubMed
9 days ago
- Approximately 23% of patients with cerebrospinal fluid-venous fistulas (CVF) treated with transvenous embolization (TVE) required retreatment.
- Most retreatment patients (74%) experienced persistent or recurrent symptoms within 3 months after the initial TVE.
- About one-third of retreatments were due to CVF recurrence at the same site and level, one-third adjacent to the original site, and one-third remote from the initial fistula.
Perspective: Depression in Persons with Parkinson's Disease - PubMed
9 days ago
- Depression in Parkinson's disease is common, affecting approximately 17% with major depressive disorder and over one-third with significant symptoms.
- Diagnosis is complicated by overlapping symptoms with PD; an inclusive diagnostic approach and PD-validated rating scales are recommended.
- Treatment follows general algorithms, including SSRIs, SNRIs, TCAs, and psychotherapy like cognitive behavioral therapy, with adjustments for PD-related vulnerabilities.
- Access to care is limited by a shortage of mental health specialists with PD expertise.
- PD serves as a model for studying mood regulation neurobiology, involving dopaminergic, serotonergic, and noradrenergic systems.
- Emerging methods such as deep brain stimulation, ecological momentary assessment, neuroimaging, and machine learning enhance understanding of emotional processing in PD.
- Future research aims to refine diagnostics, optimize therapies, and deepen insights into affective dysregulation in PD.

Hasty Briefsbeta

Neural Stem Cell-Derived Exosomes-Transmitted miR-31-5p Promote Functional Recovery of Spinal Cord Injury by Shifting Astrocytes A1/A2 Polarization - PubMed

Two-Year Outcomes of Less Invasive Surfactant Administration Among Preterm Neonates: A Secondary Analysis of a Randomized Clinical Trial - PubMed

The impact of antigen presentation on BBB disruption and neuroinflammation - PubMed

A neuropeptide regulates cell non-autonomous protein homeostasis - PubMed

Mortality impact of long-term home non-invasive ventilation in COPD patients with versus without obstructive sleep apnea - PubMed

Spirocyclic β-lactone secondary metabolites modulate spliceosome function - PubMed

Neural circuits for decision-making based on pineal photoreception in zebrafish - PubMed

Recurrent aquaporin 4-immunoglobulin G-positive neuromyelitis optica spectrum disorder in a patient with long-standing rheumatoid arthritis: A case report - PubMed

Effects of intravenous furosemide plus small-volume hypertonic saline solutions on inflammatory, remodelling markers and epigenetics signatures of patients with congestive acute decompensated heart fa

Vitamin E alleviates experimental autoimmune prostatitis by inhibiting the EGFR/MAPK pathway to reduce M1 macrophage polarization - PubMed

Mitochondrial kinase CMPK2 in immune homeostasis and disease: from metabolic regulation to inflammatory signaling - PubMed

Higher ultra-processed food consumption is associated with higher likelihood of paediatric-onset multiple sclerosis - PubMed

Association between the estimated glucose disposal rate and new-onset chronic obstructive pulmonary disease in United States adults - PubMed

Alisol B as a novel inhibitor of TβRs suppresses the growth and metastasis of non-small cell lung cancer by inhibiting TGF-β-induced epithelial-mesenchymal transition - PubMed

Cerebral small vessel disease imaging markers and disease severity in moyamoya disease: Insights from magnetic resonance imaging analysis - PubMed

Revitalizing mitochondrial quality control: targeting mitochondria-derived vesicles in Parkinson's disease - PubMed

Dual-chemokine-armed oncolytic Senecavirus A co-recruits cDC1 and CXCR3+ T cells to convert 'cold' melanoma and drive durable regression - PubMed

Effects of Kegel Exercises on Women With Urinary Incontinence: A Systematic Review and Meta-Analysis - PubMed

Rates of Retreatment after Transvenous Embolization of CSF-Venous Fistulas in Spontaneous Intracranial Hypotension - PubMed

Perspective: Depression in Persons with Parkinson's Disease - PubMed

Neural Stem Cell-Derived Exosomes-Transmitted miR-31-5p Promote Functional Recovery of Spinal Cord Injury by Shifting Astrocytes A1/A2 Polarization - PubMed

Two-Year Outcomes of Less Invasive Surfactant Administration Among Preterm Neonates: A Secondary Analysis of a Randomized Clinical Trial - PubMed

The impact of antigen presentation on BBB disruption and neuroinflammation - PubMed

A neuropeptide regulates cell non-autonomous protein homeostasis - PubMed

Mortality impact of long-term home non-invasive ventilation in COPD patients with versus without obstructive sleep apnea - PubMed

Spirocyclic β-lactone secondary metabolites modulate spliceosome function - PubMed

Neural circuits for decision-making based on pineal photoreception in zebrafish - PubMed

Recurrent aquaporin 4-immunoglobulin G-positive neuromyelitis optica spectrum disorder in a patient with long-standing rheumatoid arthritis: A case report - PubMed

Effects of intravenous furosemide plus small-volume hypertonic saline solutions on inflammatory, remodelling markers and epigenetics signatures of patients with congestive acute decompensated heart fa

Vitamin E alleviates experimental autoimmune prostatitis by inhibiting the EGFR/MAPK pathway to reduce M1 macrophage polarization - PubMed

Mitochondrial kinase CMPK2 in immune homeostasis and disease: from metabolic regulation to inflammatory signaling - PubMed

Higher ultra-processed food consumption is associated with higher likelihood of paediatric-onset multiple sclerosis - PubMed

Association between the estimated glucose disposal rate and new-onset chronic obstructive pulmonary disease in United States adults - PubMed

Alisol B as a novel inhibitor of TβRs suppresses the growth and metastasis of non-small cell lung cancer by inhibiting TGF-β-induced epithelial-mesenchymal transition - PubMed

Cerebral small vessel disease imaging markers and disease severity in moyamoya disease: Insights from magnetic resonance imaging analysis - PubMed

Revitalizing mitochondrial quality control: targeting mitochondria-derived vesicles in Parkinson's disease - PubMed

Dual-chemokine-armed oncolytic Senecavirus A co-recruits cDC1 and CXCR3+ T cells to convert 'cold' melanoma and drive durable regression - PubMed

Effects of Kegel Exercises on Women With Urinary Incontinence: A Systematic Review and Meta-Analysis - PubMed

Rates of Retreatment after Transvenous Embolization of CSF-Venous Fistulas in Spontaneous Intracranial Hypotension - PubMed

Perspective: Depression in Persons with Parkinson's Disease - PubMed