Hasty Briefsbeta

Bilingual

Everolimus destabilizes thymidylate synthase via suppressing its O-GlcNAcylation and sensitizes HER2-negative breast cancer to fluorouracil - PubMed
3 days ago
- Everolimus enhances 5-FU efficacy in HER2-negative breast cancer.
- Everolimus downregulates thymidylate synthase (TYMS) by inducing proteasomal degradation via reduced O-GlcNAcylation.
- Overexpression of O-GlcNAc transferase (OGT) reverses TYMS degradation.
- Combination strategy effective in refractory breast cancer patients.
- Decreased TYMS and OGT levels observed post-everolimus treatment in patients.
Cardiorenal outcomes of empagliflozin versus dapagliflozin in primary prevention among patients with type 2 diabetes: A nationwide cohort study - PubMed
3 days ago
- This nationwide cohort study compared empagliflozin and dapagliflozin for cardiorenal outcomes in type 2 diabetes patients without prior cardiovascular or renal disease.
- The primary outcome, a composite of cardiovascular death, myocardial infarction, stroke, heart failure hospitalization, or end-stage renal disease, showed no significant difference between the two drugs (HR 0.98, 95% CI 0.89-1.09).
- Secondary outcomes, including major adverse cardiovascular events, were also comparable, with consistent results in sensitivity analyses.
- Empagliflozin and dapagliflozin demonstrated similar effectiveness for primary prevention, suggesting clinical interchangeability in real-world practice.
Nuclear receptors in age-related diseases: from mechanisms to drug discovery - PubMed
3 days ago
- Nuclear receptors (NRs) are ligand-activated transcription factors that regulate physiological processes like development, metabolism, and homeostasis.
- Activation of specific NRs (e.g., PXR, FXR, CAR) can modulate aging hallmarks such as cellular senescence, inflammation, and autophagy.
- Dysregulation of NR signaling accelerates aging and contributes to age-related disorders like metabolic and neurodegenerative diseases.
- NRs are promising therapeutic targets for mitigating aging and developing interventions for age-related diseases.
- The review summarizes NR roles in aging hallmarks, their mechanisms in diseases, and evaluates therapeutic strategies targeting NR pathways.
Episodic Heavy Drinking and Implications for Steatotic Liver Disease Nomenclature: A National Cross-Sectional Study - PubMed
3 days ago
- Episodic heavy drinking (≥4 drinks for women, ≥5 for men at least monthly) is common in MASLD patients (15.9%).
- Episodic heavy drinking in MASLD is associated with increased odds of significant liver fibrosis (aOR 1.69) and advanced liver fibrosis (aOR 2.76).
- Including episodic heavy drinking in SLD nomenclature reclassifies patients from MASLD to MetALD, doubling MetALD prevalence (from 5.3% to 12.9%).
Microfluidic platforms for precision delivery of therapeutic cells in regenerative and personalized medicine - PubMed
3 days ago
- Microfluidic platforms address challenges in therapeutic cell delivery by enabling precise manipulation of fluids, biomaterials, and cells at microscale.
- They improve cell retention, engraftment, dose control, viability under shear, and allow site-specific placement and immunoisolation.
- These platforms mimic native tissue microenvironments and support scalable production of cell-laden carriers using advanced microfabrication techniques.
- Integration with CRISPR, synthetic biology, and sensors enables 'smart' therapeutic cells and real-time monitoring.
- Applications include stem cell purification, CAR-T cell manufacturing, and exosome-based delivery.
- Obstacles remain in regulatory standardization, large-scale manufacturing, and clinical workflow integration.
New biomarkers for the detection of fetal death derived from large-scale proteomic analysis of maternal plasma - PubMed
3 days ago
- Study identified new maternal plasma protein biomarkers to improve prediction of fetal death beyond known markers PlGF and sFlt-1.
- Analysis of over 7,000 proteins found 87 unique proteins significantly dysregulated in fetal death cases, mostly involved in pregnancy processes like angiogenesis.
- Random forest models combining new proteins with PlGF/sFlt-1 increased AUC from 72% to 86%, boosting sensitivity from 53% to 74% at similar false-positive rates.
- Top candidate biomarkers enhancing discrimination include CGA, DNAJB9, and POLR3K, with some proteins showing unique dysregulation in fetal death compared to preeclampsia.
- Proteomic changes in fetal death are correlated with late preeclampsia but represent a more severe state with distinct perturbed pathways, suggesting both shared and separate mechanisms.
Trajectories of frailty, grip strength and gait speed preceding dementia: a nested case-control study - PubMed
3 days ago
- Frailty, grip strength, and gait speed show distinct decline trajectories up to 11 years before dementia diagnosis.
- Dementia cases exhibited higher and steeper increases in frailty and faster declines in grip strength and gait speed compared to matched controls.
- Significant differences between cases and controls emerged 4-6 years before dementia onset, with gait speed being the earliest indicator.
- Functional declines were more pronounced in females and, to a lesser extent, in ApoE ε4 non-carriers.
- The study supports using functional measures like gait speed as early markers for dementia risk and targeted monitoring.
The impact of tumor location in pancreatic cancer: Survival outcomes after resection in a multi-institutional TriNetX analysis - PubMed
3 days ago
- Study used TriNetX data to compare survival outcomes of resected pancreatic ductal adenocarcinoma (PDAC) by tumor location.
- Head tumors had higher 30-day mortality (2.3% vs. 0.9%) and increased sepsis risk compared to body/tail tumors.
- Long-term mortality was greater for head tumors (39.8% vs. 31.6%), with median survival shorter (1131 vs. 2020 days).
- Findings indicate tumor location is an independent prognostic factor, supporting location-specific treatment strategies.
Effects of Vericiguat on the Mitochondrial Function and Clinical Outcomes in CRT Nonresponders Patients - PubMed
3 days ago
- Vericiguat treatment in CRT nonresponders resulted in a significantly higher CRT responder rate (42.9% vs 12.3%) and lower heart failure hospitalizations (11.1% vs 27.5%) at 1 year compared to untreated patients.
- Patients on vericiguat showed improved mitochondrial function, including reduced methoxyisobutylisonitrile washout, enhanced ATP synthesis, and increased sirtuins3-6 expression, along with reduced inflammatory/oxidative stress levels.
- Vericiguat and sacubitril/valsartan were predictors of CRT responder outcomes, while low baseline ATP was associated with increased risk of heart failure hospitalizations.
- The study concluded that vericiguat likely improves clinical outcomes in CRT nonresponders by enhancing mitochondrial function and reducing inflammation/oxidative stress, though larger studies are needed for confirmation.
Dynamic trajectories of organ dysfunction in sepsis using the SOFA-2 score and early prediction from multicenter cohorts - PubMed
3 days ago
- This study uses the SOFA-2 score to track dynamic organ dysfunction trajectories over 14 days in sepsis patients from multicenter cohorts.
- Three distinct trajectory patterns were identified: rapid recovery (36.2%), delayed recovery (45.0%), and an unfavorable persistent/severe dysfunction trajectory (18.8%), with corresponding 28-day mortality rates of 11.3%, 23.7%, and 52.4%.
- An ensemble machine-learning model was developed to predict the unfavorable trajectory early, using the first 72 hours of ICU data, achieving high AUROC scores (0.84-0.88) and providing a median 36-hour lead time for intervention.
- Implementation of a protocolized alert system based on these predictions was associated with a significant reduction in 28-day mortality (from 27.0% to 21.7%), shorter ICU stays, and reduced vasopressor duration.
- The findings suggest that dynamic SOFA-2 trajectory monitoring and early, explainable prediction models can enhance precision care, improve patient outcomes, and optimize resource use in sepsis management.
Amyloid-related imaging abnormalities in Japanese patients with Alzheimer's disease treated with Lecanemab: A real-world study - PubMed
3 days ago
- Real-world study of Japanese Alzheimer's patients treated with Lecanemab showed ARIA incidence at 20% (mostly asymptomatic), with 4% ARIA-E (all APOE ε4 carriers) and 16% isolated ARIA-H.
- Safety profile was manageable: 28% had mild infusion-related reactions, 16% discontinued treatment (mainly due to disease progression), and no symptomatic ARIA occurred.
- Exploratory analyses indicated trends linking ARIA risk to lower baseline MMSE scores, higher plasma GFAP levels, and higher deep white matter Fazekas scores, highlighting need for individualized risk assessment.
A dual-transformable MgGa-MOF nanoplatform for HCC therapy via lactate metabolism blockade and immune reactivation - PubMed
3 days ago
- Dual-transformable MgGa-MOF nanoplatform (DMGTF NCs) developed for HCC therapy by blocking lactate metabolism and reactivating immunity post-MWA.
- Microwave ablation (MWA) is limited by lactate accumulation, which fuels residual tumor cells, acidifies TME, and impairs immune function, leading to recurrence/metastasis.
- DMGTF NCs release diclofenac sodium (Dis) upon microwave irradiation, suppressing MCT4-mediated lactate efflux to disrupt energy supply and reshape TME.
- Microwave-activated DMGTF generates ROS to impair mitochondrial lactate oxidation, increasing intracellular lactate accumulation and inducing metabolic stress.
- Framework-derived Mg²⁺ reactivates T cells, boosting proliferation and IFN-γ secretion, converting immunosuppressive pressure into antitumor power.
- Combination of DMGTF NCs with MWA achieves excellent therapeutic effects in HCC and lung metastasis models, addressing post-MWA relapse challenges.
Comparative Efficacy and Safety of Ecnoglutide in Type 2 Diabetes: A Systematic Review and Meta-Analysis - PubMed
3 days ago
- Ecnoglutide, a novel long-acting GLP-1 receptor agonist, shows promise for treating Type 2 Diabetes Mellitus (T2DM), which affects over 500 million people globally.
- A meta-analysis of four randomized controlled trials (total 1643 participants) found ecnoglutide significantly reduces HbA1c, body weight, and fasting plasma glucose, with improvements in insulin sensitivity, lipid profile, and liver enzymes.
- Adverse events, primarily gastrointestinal and mild-to-moderate, were more common with ecnoglutide, but serious adverse events did not differ significantly from comparators.
- The study concludes that ecnoglutide offers robust efficacy for glycemic control and weight reduction with an acceptable safety profile, supporting its potential as a next-generation GLP-1 agonist.
Alpha Oscillations and Conditioned Pain Modulation Is Associated With Treatment Resistance to Spinal Cord Stimulation for Neuropathic Pain - PubMed
3 days ago
- Spinal cord stimulation (SCS) treatment resistance in neuropathic pain is linked to abnormal alpha oscillations and inefficient conditioned pain modulation (CPM).
- Pre-SCS testing showed that responders had lower alpha power in specific brain networks, while nonresponders exhibited abnormal CPM and reduced peak alpha frequency in the subgenual anterior cingulate cortex.
- These brain-behavioral measures may serve as predictive markers for SCS outcomes, aiding personalized pain management strategies.
Novel insights of acupuncture in ischemic stroke: orchestrating neuro-endocrine-immune network - PubMed
3 days ago
- Acupuncture is a holistic, non-pharmaceutical therapy with potential to address multi-system imbalances following ischemic stroke (IS).
- The pathology of IS involves dysfunction of the neuro-endocrine-immune (NEI) network, progressing from local ischemia to a systemic disorder.
- Acupuncture modulates the NEI network through mechanisms like the cholinergic anti-inflammatory pathway and the brain-gut axis, synergistically regulating neural, hormonal, and inflammatory responses.
- This review provides insights into acupuncture's mechanisms, indicating a shift from empirical treatment towards precision medicine for IS.
Hydrogen gas (H2) pretreatment improves lipopolysaccharide-induced acute liver injury in mice by inhibiting NLRP3 inflammasome activation and pyroptosis signaling - PubMed
3 days ago
- Hydrogen gas (H2) pretreatment via intraperitoneal injection improves acute liver injury induced by lipopolysaccharide (LPS) in mice.
- H2 reduces inflammatory cell infiltration, lowers serum ALT and AST levels, and modulates oxidative stress markers (decreases 3-nitrotyrosine, MDA, MPO; increases GSH).
- Mechanistically, H2 inhibits TLR4-mediated signaling pathways (IKK-NF-κB and MAPK), leading to reduced pro-inflammatory cytokines (TNF-α, IL-1β, IL-18).
- H2 suppresses NLRP3 inflammasome activation (NLRP3, ASC, Caspase-1) and pyroptosis signaling involving GSDMD, Caspase-8/11, Caspase-3, and GSDME, as shown by reduced TUNEL staining.
- Pharmacological experiments using NLRP3 agonist (nigericin) and antagonist (MCC950) confirm H2's action on NLRP3 in vitro.
- H2 alleviates LPS-induced acute liver injury by modulating redox homeostasis, innate immune signaling, NLRP3 inflammasome, and pyroptosis.
Hyperglycemia During Acute Pancreatitis and Progression to Early-Onset Diabetes After Recovery: Preliminary Findings From the Diabetes Related to Acute Pancreatitis and Its Mechanisms (DREAM) Study -
3 days ago
- HDAP prevalence in non-diabetic AP patients was 37.5% using a glucose threshold of >140 mg/dL and 7.1% for >200 mg/dL.
- HDAP significantly predicted early-onset diabetes post-AP: 14.8% with HDAP140 and 42.9% with HDAP200 developed diabetes, compared to 1.2% and 3.5% without, respectively.
- Absence of HDAP showed high negative predictive values (99% for HDAP140, 97% for HDAP200) for diabetes risk.
- Monitoring glycemia during AP can help identify high-risk patients for targeted post-discharge care.
Ceftazidime-avibactam resistance evolution in Pseudomonas aeruginosa and implications for cross-resistance to other novel β-lactams - PubMed
3 days ago
- Ceftazidime-avibactam resistance evolution in Pseudomonas aeruginosa was studied using 12 patient isolate pairs.
- Resistance mechanisms included amino acid substitutions in AmpC and OXA β-lactamases, and regulatory mutations causing hyper-production of AmpC and MexAB-OprM efflux pumps.
- Cross-resistance was common with ceftolozane-tazobactam, less common with imipenem-relebactam and cefepime-zidebactam, and lowest with cefiderocol.
- Findings have important implications for sequential treatment of P. aeruginosa infections.
High Response Rates and Predictors in Patients with CRSwNP Treated With Mepolizumab and Dupilumab: Results From a Prospective, Multicenter Cohort Study - PubMed
3 days ago
- Dupilumab and mepolizumab are effective add-on therapies for severe CRSwNP (chronic rhinosinusitis with nasal polyps).
- Study aimed to identify baseline predictors of response and compare outcomes between dupilumab and mepolizumab at 6 and 12 months.
- Both biologics significantly improved SNOT-22, total symptom score (TSS), and nasal polyp score (NPS) at both time points with comparable efficacy.
- Dupilumab showed superior improvement in olfaction compared to mepolizumab.
- High response rates: 84.2% achieved good/excellent response at 6 months and 89.6% at 12 months.
- Factors associated with better response included comorbid asthma and a shorter time since the last surgery.
- Asthma and surgical history may help predict response to these biologics.
Accuracy of muscle ultrasonography in detecting fasciculations for the diagnosis of amyotrophic lateral sclerosis: a systematic review and meta-analysis - PubMed
3 days ago
- This systematic review and meta-analysis evaluated muscle ultrasonography for detecting fasciculations in amyotrophic lateral sclerosis (ALS) diagnosis.
- It analyzed 13 studies with 1176 participants, finding pooled sensitivity of 0.87, specificity of 0.91, and an area under the SROC curve of 0.94.
- Scan duration significantly affected accuracy, with ≥30 seconds improving sensitivity but reducing specificity; no significant publication bias was detected.
- The method showed good diagnostic accuracy, potentially serving as a useful adjunct to electrodiagnostic evaluation in ALS diagnosis.

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Bilingual

Everolimus destabilizes thymidylate synthase via suppressing its O-GlcNAcylation and sensitizes HER2-negative breast cancer to fluorouracil - PubMed
3 days ago
- Everolimus enhances 5-FU efficacy in HER2-negative breast cancer.
- Everolimus downregulates thymidylate synthase (TYMS) by inducing proteasomal degradation via reduced O-GlcNAcylation.
- Overexpression of O-GlcNAc transferase (OGT) reverses TYMS degradation.
- Combination strategy effective in refractory breast cancer patients.
- Decreased TYMS and OGT levels observed post-everolimus treatment in patients.
Cardiorenal outcomes of empagliflozin versus dapagliflozin in primary prevention among patients with type 2 diabetes: A nationwide cohort study - PubMed
3 days ago
- This nationwide cohort study compared empagliflozin and dapagliflozin for cardiorenal outcomes in type 2 diabetes patients without prior cardiovascular or renal disease.
- The primary outcome, a composite of cardiovascular death, myocardial infarction, stroke, heart failure hospitalization, or end-stage renal disease, showed no significant difference between the two drugs (HR 0.98, 95% CI 0.89-1.09).
- Secondary outcomes, including major adverse cardiovascular events, were also comparable, with consistent results in sensitivity analyses.
- Empagliflozin and dapagliflozin demonstrated similar effectiveness for primary prevention, suggesting clinical interchangeability in real-world practice.
Nuclear receptors in age-related diseases: from mechanisms to drug discovery - PubMed
3 days ago
- Nuclear receptors (NRs) are ligand-activated transcription factors that regulate physiological processes like development, metabolism, and homeostasis.
- Activation of specific NRs (e.g., PXR, FXR, CAR) can modulate aging hallmarks such as cellular senescence, inflammation, and autophagy.
- Dysregulation of NR signaling accelerates aging and contributes to age-related disorders like metabolic and neurodegenerative diseases.
- NRs are promising therapeutic targets for mitigating aging and developing interventions for age-related diseases.
- The review summarizes NR roles in aging hallmarks, their mechanisms in diseases, and evaluates therapeutic strategies targeting NR pathways.
Episodic Heavy Drinking and Implications for Steatotic Liver Disease Nomenclature: A National Cross-Sectional Study - PubMed
3 days ago
- Episodic heavy drinking (≥4 drinks for women, ≥5 for men at least monthly) is common in MASLD patients (15.9%).
- Episodic heavy drinking in MASLD is associated with increased odds of significant liver fibrosis (aOR 1.69) and advanced liver fibrosis (aOR 2.76).
- Including episodic heavy drinking in SLD nomenclature reclassifies patients from MASLD to MetALD, doubling MetALD prevalence (from 5.3% to 12.9%).
Microfluidic platforms for precision delivery of therapeutic cells in regenerative and personalized medicine - PubMed
3 days ago
- Microfluidic platforms address challenges in therapeutic cell delivery by enabling precise manipulation of fluids, biomaterials, and cells at microscale.
- They improve cell retention, engraftment, dose control, viability under shear, and allow site-specific placement and immunoisolation.
- These platforms mimic native tissue microenvironments and support scalable production of cell-laden carriers using advanced microfabrication techniques.
- Integration with CRISPR, synthetic biology, and sensors enables 'smart' therapeutic cells and real-time monitoring.
- Applications include stem cell purification, CAR-T cell manufacturing, and exosome-based delivery.
- Obstacles remain in regulatory standardization, large-scale manufacturing, and clinical workflow integration.
New biomarkers for the detection of fetal death derived from large-scale proteomic analysis of maternal plasma - PubMed
3 days ago
- Study identified new maternal plasma protein biomarkers to improve prediction of fetal death beyond known markers PlGF and sFlt-1.
- Analysis of over 7,000 proteins found 87 unique proteins significantly dysregulated in fetal death cases, mostly involved in pregnancy processes like angiogenesis.
- Random forest models combining new proteins with PlGF/sFlt-1 increased AUC from 72% to 86%, boosting sensitivity from 53% to 74% at similar false-positive rates.
- Top candidate biomarkers enhancing discrimination include CGA, DNAJB9, and POLR3K, with some proteins showing unique dysregulation in fetal death compared to preeclampsia.
- Proteomic changes in fetal death are correlated with late preeclampsia but represent a more severe state with distinct perturbed pathways, suggesting both shared and separate mechanisms.
Trajectories of frailty, grip strength and gait speed preceding dementia: a nested case-control study - PubMed
3 days ago
- Frailty, grip strength, and gait speed show distinct decline trajectories up to 11 years before dementia diagnosis.
- Dementia cases exhibited higher and steeper increases in frailty and faster declines in grip strength and gait speed compared to matched controls.
- Significant differences between cases and controls emerged 4-6 years before dementia onset, with gait speed being the earliest indicator.
- Functional declines were more pronounced in females and, to a lesser extent, in ApoE ε4 non-carriers.
- The study supports using functional measures like gait speed as early markers for dementia risk and targeted monitoring.
The impact of tumor location in pancreatic cancer: Survival outcomes after resection in a multi-institutional TriNetX analysis - PubMed
3 days ago
- Study used TriNetX data to compare survival outcomes of resected pancreatic ductal adenocarcinoma (PDAC) by tumor location.
- Head tumors had higher 30-day mortality (2.3% vs. 0.9%) and increased sepsis risk compared to body/tail tumors.
- Long-term mortality was greater for head tumors (39.8% vs. 31.6%), with median survival shorter (1131 vs. 2020 days).
- Findings indicate tumor location is an independent prognostic factor, supporting location-specific treatment strategies.
Effects of Vericiguat on the Mitochondrial Function and Clinical Outcomes in CRT Nonresponders Patients - PubMed
3 days ago
- Vericiguat treatment in CRT nonresponders resulted in a significantly higher CRT responder rate (42.9% vs 12.3%) and lower heart failure hospitalizations (11.1% vs 27.5%) at 1 year compared to untreated patients.
- Patients on vericiguat showed improved mitochondrial function, including reduced methoxyisobutylisonitrile washout, enhanced ATP synthesis, and increased sirtuins3-6 expression, along with reduced inflammatory/oxidative stress levels.
- Vericiguat and sacubitril/valsartan were predictors of CRT responder outcomes, while low baseline ATP was associated with increased risk of heart failure hospitalizations.
- The study concluded that vericiguat likely improves clinical outcomes in CRT nonresponders by enhancing mitochondrial function and reducing inflammation/oxidative stress, though larger studies are needed for confirmation.
Dynamic trajectories of organ dysfunction in sepsis using the SOFA-2 score and early prediction from multicenter cohorts - PubMed
3 days ago
- This study uses the SOFA-2 score to track dynamic organ dysfunction trajectories over 14 days in sepsis patients from multicenter cohorts.
- Three distinct trajectory patterns were identified: rapid recovery (36.2%), delayed recovery (45.0%), and an unfavorable persistent/severe dysfunction trajectory (18.8%), with corresponding 28-day mortality rates of 11.3%, 23.7%, and 52.4%.
- An ensemble machine-learning model was developed to predict the unfavorable trajectory early, using the first 72 hours of ICU data, achieving high AUROC scores (0.84-0.88) and providing a median 36-hour lead time for intervention.
- Implementation of a protocolized alert system based on these predictions was associated with a significant reduction in 28-day mortality (from 27.0% to 21.7%), shorter ICU stays, and reduced vasopressor duration.
- The findings suggest that dynamic SOFA-2 trajectory monitoring and early, explainable prediction models can enhance precision care, improve patient outcomes, and optimize resource use in sepsis management.
Amyloid-related imaging abnormalities in Japanese patients with Alzheimer's disease treated with Lecanemab: A real-world study - PubMed
3 days ago
- Real-world study of Japanese Alzheimer's patients treated with Lecanemab showed ARIA incidence at 20% (mostly asymptomatic), with 4% ARIA-E (all APOE ε4 carriers) and 16% isolated ARIA-H.
- Safety profile was manageable: 28% had mild infusion-related reactions, 16% discontinued treatment (mainly due to disease progression), and no symptomatic ARIA occurred.
- Exploratory analyses indicated trends linking ARIA risk to lower baseline MMSE scores, higher plasma GFAP levels, and higher deep white matter Fazekas scores, highlighting need for individualized risk assessment.
A dual-transformable MgGa-MOF nanoplatform for HCC therapy via lactate metabolism blockade and immune reactivation - PubMed
3 days ago
- Dual-transformable MgGa-MOF nanoplatform (DMGTF NCs) developed for HCC therapy by blocking lactate metabolism and reactivating immunity post-MWA.
- Microwave ablation (MWA) is limited by lactate accumulation, which fuels residual tumor cells, acidifies TME, and impairs immune function, leading to recurrence/metastasis.
- DMGTF NCs release diclofenac sodium (Dis) upon microwave irradiation, suppressing MCT4-mediated lactate efflux to disrupt energy supply and reshape TME.
- Microwave-activated DMGTF generates ROS to impair mitochondrial lactate oxidation, increasing intracellular lactate accumulation and inducing metabolic stress.
- Framework-derived Mg²⁺ reactivates T cells, boosting proliferation and IFN-γ secretion, converting immunosuppressive pressure into antitumor power.
- Combination of DMGTF NCs with MWA achieves excellent therapeutic effects in HCC and lung metastasis models, addressing post-MWA relapse challenges.
Comparative Efficacy and Safety of Ecnoglutide in Type 2 Diabetes: A Systematic Review and Meta-Analysis - PubMed
3 days ago
- Ecnoglutide, a novel long-acting GLP-1 receptor agonist, shows promise for treating Type 2 Diabetes Mellitus (T2DM), which affects over 500 million people globally.
- A meta-analysis of four randomized controlled trials (total 1643 participants) found ecnoglutide significantly reduces HbA1c, body weight, and fasting plasma glucose, with improvements in insulin sensitivity, lipid profile, and liver enzymes.
- Adverse events, primarily gastrointestinal and mild-to-moderate, were more common with ecnoglutide, but serious adverse events did not differ significantly from comparators.
- The study concludes that ecnoglutide offers robust efficacy for glycemic control and weight reduction with an acceptable safety profile, supporting its potential as a next-generation GLP-1 agonist.
Alpha Oscillations and Conditioned Pain Modulation Is Associated With Treatment Resistance to Spinal Cord Stimulation for Neuropathic Pain - PubMed
3 days ago
- Spinal cord stimulation (SCS) treatment resistance in neuropathic pain is linked to abnormal alpha oscillations and inefficient conditioned pain modulation (CPM).
- Pre-SCS testing showed that responders had lower alpha power in specific brain networks, while nonresponders exhibited abnormal CPM and reduced peak alpha frequency in the subgenual anterior cingulate cortex.
- These brain-behavioral measures may serve as predictive markers for SCS outcomes, aiding personalized pain management strategies.
Novel insights of acupuncture in ischemic stroke: orchestrating neuro-endocrine-immune network - PubMed
3 days ago
- Acupuncture is a holistic, non-pharmaceutical therapy with potential to address multi-system imbalances following ischemic stroke (IS).
- The pathology of IS involves dysfunction of the neuro-endocrine-immune (NEI) network, progressing from local ischemia to a systemic disorder.
- Acupuncture modulates the NEI network through mechanisms like the cholinergic anti-inflammatory pathway and the brain-gut axis, synergistically regulating neural, hormonal, and inflammatory responses.
- This review provides insights into acupuncture's mechanisms, indicating a shift from empirical treatment towards precision medicine for IS.
Hydrogen gas (H2) pretreatment improves lipopolysaccharide-induced acute liver injury in mice by inhibiting NLRP3 inflammasome activation and pyroptosis signaling - PubMed
3 days ago
- Hydrogen gas (H2) pretreatment via intraperitoneal injection improves acute liver injury induced by lipopolysaccharide (LPS) in mice.
- H2 reduces inflammatory cell infiltration, lowers serum ALT and AST levels, and modulates oxidative stress markers (decreases 3-nitrotyrosine, MDA, MPO; increases GSH).
- Mechanistically, H2 inhibits TLR4-mediated signaling pathways (IKK-NF-κB and MAPK), leading to reduced pro-inflammatory cytokines (TNF-α, IL-1β, IL-18).
- H2 suppresses NLRP3 inflammasome activation (NLRP3, ASC, Caspase-1) and pyroptosis signaling involving GSDMD, Caspase-8/11, Caspase-3, and GSDME, as shown by reduced TUNEL staining.
- Pharmacological experiments using NLRP3 agonist (nigericin) and antagonist (MCC950) confirm H2's action on NLRP3 in vitro.
- H2 alleviates LPS-induced acute liver injury by modulating redox homeostasis, innate immune signaling, NLRP3 inflammasome, and pyroptosis.
Hyperglycemia During Acute Pancreatitis and Progression to Early-Onset Diabetes After Recovery: Preliminary Findings From the Diabetes Related to Acute Pancreatitis and Its Mechanisms (DREAM) Study -
3 days ago
- HDAP prevalence in non-diabetic AP patients was 37.5% using a glucose threshold of >140 mg/dL and 7.1% for >200 mg/dL.
- HDAP significantly predicted early-onset diabetes post-AP: 14.8% with HDAP140 and 42.9% with HDAP200 developed diabetes, compared to 1.2% and 3.5% without, respectively.
- Absence of HDAP showed high negative predictive values (99% for HDAP140, 97% for HDAP200) for diabetes risk.
- Monitoring glycemia during AP can help identify high-risk patients for targeted post-discharge care.
Ceftazidime-avibactam resistance evolution in Pseudomonas aeruginosa and implications for cross-resistance to other novel β-lactams - PubMed
3 days ago
- Ceftazidime-avibactam resistance evolution in Pseudomonas aeruginosa was studied using 12 patient isolate pairs.
- Resistance mechanisms included amino acid substitutions in AmpC and OXA β-lactamases, and regulatory mutations causing hyper-production of AmpC and MexAB-OprM efflux pumps.
- Cross-resistance was common with ceftolozane-tazobactam, less common with imipenem-relebactam and cefepime-zidebactam, and lowest with cefiderocol.
- Findings have important implications for sequential treatment of P. aeruginosa infections.
High Response Rates and Predictors in Patients with CRSwNP Treated With Mepolizumab and Dupilumab: Results From a Prospective, Multicenter Cohort Study - PubMed
3 days ago
- Dupilumab and mepolizumab are effective add-on therapies for severe CRSwNP (chronic rhinosinusitis with nasal polyps).
- Study aimed to identify baseline predictors of response and compare outcomes between dupilumab and mepolizumab at 6 and 12 months.
- Both biologics significantly improved SNOT-22, total symptom score (TSS), and nasal polyp score (NPS) at both time points with comparable efficacy.
- Dupilumab showed superior improvement in olfaction compared to mepolizumab.
- High response rates: 84.2% achieved good/excellent response at 6 months and 89.6% at 12 months.
- Factors associated with better response included comorbid asthma and a shorter time since the last surgery.
- Asthma and surgical history may help predict response to these biologics.
Accuracy of muscle ultrasonography in detecting fasciculations for the diagnosis of amyotrophic lateral sclerosis: a systematic review and meta-analysis - PubMed
3 days ago
- This systematic review and meta-analysis evaluated muscle ultrasonography for detecting fasciculations in amyotrophic lateral sclerosis (ALS) diagnosis.
- It analyzed 13 studies with 1176 participants, finding pooled sensitivity of 0.87, specificity of 0.91, and an area under the SROC curve of 0.94.
- Scan duration significantly affected accuracy, with ≥30 seconds improving sensitivity but reducing specificity; no significant publication bias was detected.
- The method showed good diagnostic accuracy, potentially serving as a useful adjunct to electrodiagnostic evaluation in ALS diagnosis.

Hasty Briefsbeta

Everolimus destabilizes thymidylate synthase via suppressing its O-GlcNAcylation and sensitizes HER2-negative breast cancer to fluorouracil - PubMed

Cardiorenal outcomes of empagliflozin versus dapagliflozin in primary prevention among patients with type 2 diabetes: A nationwide cohort study - PubMed

Nuclear receptors in age-related diseases: from mechanisms to drug discovery - PubMed

Episodic Heavy Drinking and Implications for Steatotic Liver Disease Nomenclature: A National Cross-Sectional Study - PubMed

Microfluidic platforms for precision delivery of therapeutic cells in regenerative and personalized medicine - PubMed

New biomarkers for the detection of fetal death derived from large-scale proteomic analysis of maternal plasma - PubMed

Trajectories of frailty, grip strength and gait speed preceding dementia: a nested case-control study - PubMed

The impact of tumor location in pancreatic cancer: Survival outcomes after resection in a multi-institutional TriNetX analysis - PubMed

Effects of Vericiguat on the Mitochondrial Function and Clinical Outcomes in CRT Nonresponders Patients - PubMed

Dynamic trajectories of organ dysfunction in sepsis using the SOFA-2 score and early prediction from multicenter cohorts - PubMed

Amyloid-related imaging abnormalities in Japanese patients with Alzheimer's disease treated with Lecanemab: A real-world study - PubMed

A dual-transformable MgGa-MOF nanoplatform for HCC therapy via lactate metabolism blockade and immune reactivation - PubMed

Comparative Efficacy and Safety of Ecnoglutide in Type 2 Diabetes: A Systematic Review and Meta-Analysis - PubMed

Alpha Oscillations and Conditioned Pain Modulation Is Associated With Treatment Resistance to Spinal Cord Stimulation for Neuropathic Pain - PubMed

Novel insights of acupuncture in ischemic stroke: orchestrating neuro-endocrine-immune network - PubMed

Hydrogen gas (H2) pretreatment improves lipopolysaccharide-induced acute liver injury in mice by inhibiting NLRP3 inflammasome activation and pyroptosis signaling - PubMed

Hyperglycemia During Acute Pancreatitis and Progression to Early-Onset Diabetes After Recovery: Preliminary Findings From the Diabetes Related to Acute Pancreatitis and Its Mechanisms (DREAM) Study -

Ceftazidime-avibactam resistance evolution in Pseudomonas aeruginosa and implications for cross-resistance to other novel β-lactams - PubMed

High Response Rates and Predictors in Patients with CRSwNP Treated With Mepolizumab and Dupilumab: Results From a Prospective, Multicenter Cohort Study - PubMed

Accuracy of muscle ultrasonography in detecting fasciculations for the diagnosis of amyotrophic lateral sclerosis: a systematic review and meta-analysis - PubMed

Everolimus destabilizes thymidylate synthase via suppressing its O-GlcNAcylation and sensitizes HER2-negative breast cancer to fluorouracil - PubMed

Cardiorenal outcomes of empagliflozin versus dapagliflozin in primary prevention among patients with type 2 diabetes: A nationwide cohort study - PubMed

Nuclear receptors in age-related diseases: from mechanisms to drug discovery - PubMed

Episodic Heavy Drinking and Implications for Steatotic Liver Disease Nomenclature: A National Cross-Sectional Study - PubMed

Microfluidic platforms for precision delivery of therapeutic cells in regenerative and personalized medicine - PubMed

New biomarkers for the detection of fetal death derived from large-scale proteomic analysis of maternal plasma - PubMed

Trajectories of frailty, grip strength and gait speed preceding dementia: a nested case-control study - PubMed

The impact of tumor location in pancreatic cancer: Survival outcomes after resection in a multi-institutional TriNetX analysis - PubMed

Effects of Vericiguat on the Mitochondrial Function and Clinical Outcomes in CRT Nonresponders Patients - PubMed

Dynamic trajectories of organ dysfunction in sepsis using the SOFA-2 score and early prediction from multicenter cohorts - PubMed

Amyloid-related imaging abnormalities in Japanese patients with Alzheimer's disease treated with Lecanemab: A real-world study - PubMed

A dual-transformable MgGa-MOF nanoplatform for HCC therapy via lactate metabolism blockade and immune reactivation - PubMed

Comparative Efficacy and Safety of Ecnoglutide in Type 2 Diabetes: A Systematic Review and Meta-Analysis - PubMed

Alpha Oscillations and Conditioned Pain Modulation Is Associated With Treatment Resistance to Spinal Cord Stimulation for Neuropathic Pain - PubMed

Novel insights of acupuncture in ischemic stroke: orchestrating neuro-endocrine-immune network - PubMed

Hydrogen gas (H2) pretreatment improves lipopolysaccharide-induced acute liver injury in mice by inhibiting NLRP3 inflammasome activation and pyroptosis signaling - PubMed

Hyperglycemia During Acute Pancreatitis and Progression to Early-Onset Diabetes After Recovery: Preliminary Findings From the Diabetes Related to Acute Pancreatitis and Its Mechanisms (DREAM) Study -

Ceftazidime-avibactam resistance evolution in Pseudomonas aeruginosa and implications for cross-resistance to other novel β-lactams - PubMed

High Response Rates and Predictors in Patients with CRSwNP Treated With Mepolizumab and Dupilumab: Results From a Prospective, Multicenter Cohort Study - PubMed

Accuracy of muscle ultrasonography in detecting fasciculations for the diagnosis of amyotrophic lateral sclerosis: a systematic review and meta-analysis - PubMed