A multi-organ metabolomics atlas reveals molecular dysregulations in Alzheimer's disease mouse models - PubMed
4 hours ago
- #Metabolomics
- #Alzheimer's Disease
- #Gut Microbiota
- A multi-organ metabolomics atlas was created using two Alzheimer's disease (AD) mouse models (3xTg and 5xFAD), analyzing over 2,000 samples.
- Systems-level analyses identified clusters of dysregulated molecules across tissues, including carnitines, bile acids, B vitamins, neurotransmitters, and N-acyl lipids.
- Metabolic shifts were linked to changes in gut microbiota, specifically depletion of Akkermansia muciniphila and enrichment of Mucispirillum schaedleri in the 3xTg model.
- Newly discovered carnitines related to microbial phenylalanine metabolism were identified.
- The developed tool tissueMASST translated findings to human samples, revealing phenylacetyl-carnitine associations with aging, cognitive impairment, and memory decline in over 1,400 human plasma and serum samples.
- This public resource and tools are intended to support future research into AD etiology.