RUNX1-regulated ITGB1-enriched extracellular vesicles drive pancreatic cancer liver metastasis via fibrotic pre-metastatic niche formation - PubMed
3 hours ago
- #Liver Metastasis
- #Extracellular Vesicles
- #Pancreatic Cancer
- RUNX1 upregulation in primary pancreatic cancer correlates with liver metastasis.
- RUNX1 transcriptionally increases ITGB1, which is enriched in extracellular vesicles (EVs).
- ITGB1-enriched EVs are taken up by hepatic stellate cells (HSCs), activating NF-κB.
- Activated HSCs secrete ECM proteins and inflammatory factors, forming a fibrotic pre-metastatic niche.
- This niche promotes pancreatic cancer liver metastasis, and plasma EV ITGB1 serves as a diagnostic biomarker.