CD8 regulatory T cells are a novel type regulatory T cells in the induction of transplantation immune tolerance - PubMed
3 hours ago
- #immune regulation
- #transplantation tolerance
- #regulatory T cells
- CD8+ regulatory T cells (CD8+CD45RClow/- Tregs) are a novel subset implicated in transplantation immune tolerance.
- In a rat liver transplantation model, adoptive infusion of tolerogenic dendritic cells (tolDCs) prolonged graft survival and increased frequencies of both CD4+Foxp3+ and CD8+CD45RClow/- Tregs.
- MHC-II+CD8+CD45RClow/- Tregs were enriched within tolerant grafts, suggesting local immune regulation.
- In liver transplant recipients, higher peripheral CD8+CD45RClow/- Treg frequencies were associated with long-term stable graft function compared to acute rejection.
- CD8+CD45RClow/- Tregs may cooperate with CD4+Foxp3+ Tregs to maintain a tolerant immune microenvironment.