QSOX1 confers ferroptosis resistance via redox modification of SLC7A11 in colorectal cancer - PubMed
3 days ago
- #redox modification
- #ferroptosis
- #colorectal cancer
- QSOX1 promotes ferroptosis resistance in colorectal cancer (CRC) cells by modifying SLC7A11 through redox regulation.
- QSOX1 interacts with SLC7A11, enhancing its membrane localization and activity, which boosts cystine uptake and glutathione synthesis, suppressing ferroptosis.
- Targeting the QSOX1-SLC7A11 axis could be a therapeutic strategy to overcome ferroptosis resistance in CRC treatment.