PPT1 selectively depalmitoylates GAP43 to regulate neuronal excitability and cognitive function - PubMed
3 hours ago
- #neurobiology
- #palmitoylation
- #cognitive function
- PPT1 selectively depalmitoylates GAP43 at Cys3 and Cys4.
- Disruption of PPT1-GAP43 interaction leads to GAP43 hyperpalmitoylation, causing excessive dendritic arborization and aberrant growth cone expansion.
- Hyperpalmitoylation enhances glutamatergic transmission and hippocampal network hyperexcitability, resulting in cognitive deficits.
- Exogenous PPT1 can reduce these morphological and synaptic abnormalities.
- The PPT1-GAP43 pathway is essential for neuronal circuit homeostasis and its dysfunction may contribute to neurodevelopmental disorders.