In vivo profiling of astrocyte secretome reveals brain-region specific regulatory networks in a mouse model of amyloid pathology - PubMed
2 hours ago
- #Alzheimer's disease
- #astrocyte secretome
- #brain-region specificity
- The study used in vivo TurboID proximity labeling to profile the astrocyte-derived secretome in a mouse model of amyloid pathology, revealing brain-region specific regulatory networks in Alzheimer's disease.
- Early alterations in the astrocyte secretome were found in the entorhinal cortex, enriched in metabolic pathways, suggesting involvement in early AD pathogenesis.
- Later changes in the hippocampus correlated with neuronal and synaptic maintenance, indicating a role in neurodegeneration and cognitive decline.
- The research provides a systematic map of dynamic, region-specific remodeling of the astrocyte secretome, identifying novel spatiotemporal vulnerabilities and potential therapeutic targets for AD.