How does type 2 diabetes modify the risk of Alzheimer's disease? - PubMed

5 hours ago

Type 2 diabetes (T2D) is a modifiable risk factor for dementia, potentially promoting it via vascular or Alzheimer's disease (AD) neuropathological changes.
The mechanism likely involves peripheral lipid anomalies and inflammation in T2D reducing blood-brain barrier integrity, enabling aberrant immune signaling between the periphery and brain.
This process promotes AD-specific microglial subtypes, which may be targeted therapeutically through the triggering receptor expressed on myeloid cells 2-apolipoprotein E signaling pathway.

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