Cell-to-cell variability and gain of methylation at polycomb CpG islands as a hallmark of aging - PubMed
3 hours ago
- #Epigenetics
- #Cellular aging
- #DNA methylation
- Aging is a complex process impacting cellular function and tissue homeostasis.
- Methylation at polycomb CpG islands serves as a predictive indicator of aging-related phenotypic changes.
- Single-cell analysis reveals that polycomb CpG island methylation preferentially occurs in a subset of cells within a population.
- Aging rates vary among cells, with faster-proliferating cells showing accelerated gain of methylation.
- Differential gene expression analysis links aging to changes in immune response, translation, tumorigenesis, and neurodegeneration.
- The findings suggest aging is a highly individualized process at the single-cell level, driven by programmed changes in polycomb CpG island DNA methylation.