The physiological effects of APOE genotype in healthy young/middle-aged individuals - PubMed
3 hours ago
- #disease risk factors
- #APOE genotype
- #physiological effects
- The APOE ε4 allele is a risk factor for cardiovascular and neurodegenerative diseases, like Alzheimer's, affecting physiological functions from infancy to adulthood in healthy young/middle-aged individuals.
- APOE genotype influences multiple physiological processes including reproduction, cardiovascular health, inflammation, lipid metabolism, cognition, and brain structure/function, with noted differences between males and females.
- APOE genotype mediates responses to external factors such as traumatic brain injury, pollution, lifestyle, and viral infections, illustrating its role in disease development and prevention strategies.
- The evolutionary perspective and 'antagonistic pleiotropy' hypothesis are discussed to explain the dual roles of APOE4 in disease risk and physiological functions across the lifespan.