Plasma proteomics reveal key proteins mediating vascular aging - PubMed
3 hours ago
- #Mendelian randomization
- #plasma proteomics
- #vascular aging
- The study identifies four plasma proteins (PCSK9, FES, TMEM106B, and FURIN) as potential causal mediators of vascular aging through Mendelian randomization and genetic colocalization.
- Mediation analysis shows that low-density lipoprotein cholesterol and systolic blood pressure mediate 26.7% to 75.3% of these proteins' effects on vascular aging.
- Phenome-wide association studies (PheWAS) validate the broader phenotypic impact of these proteins, highlighting blood pressure and lipids as key pathways in vascular aging.