Endothelial Estrogen Receptor Alpha Inhibits Plaque Inflammation in Both Sexes - PubMed
3 hours ago
- #Plaque Inflammation
- #Atherosclerosis
- #Estrogen Receptor Alpha
- Atherosclerotic plaque inflammation links to rupture and myocardial infarction risk.
- Young women have lower heart attack risk than men until menopause, implicating estrogen receptors (ER).
- EC-specific ERα knockout in mice increased plaque inflammation and adhesion molecule expression in both sexes.
- Human endothelial cells from young women expressed more ERα and less ICAM1 than those from age-matched men.
- ERα knockdown in human coronary ECs from both sexes raised adhesion molecule levels.
- Estrogen blocked aldosterone-induced ICAM1 expression and MR recruitment on ICAM1 promoter in human ECs.
- Female mice: EC-MR knockout did not affect inflammation, as ERα already inhibits MR function.
- Male mice: EC-MR knockout reduced inflammation, with ERα and MR offsetting each other's effects.
- ERα regulates plaque inflammation in both sexes: inhibits MR-driven ICAM1 in females and counteracts MR in males.