Lamprey 3D single-cell transcriptomics reveals ancestral and specialized features of the vertebrate brain - PubMed
4 hours ago
- #lamprey brain
- #single-cell transcriptomics
- #vertebrate evolution
- Lamprey 3D single-cell transcriptomics provides insights into ancestral and specialized features of the vertebrate brain.
- A molecular atlas of the lamprey brain identified 209 distinct cell clusters across 14 regions.
- Cross-species comparisons reveal broad conservation of regional spatial architecture, indicating an ancestral organizational blueprint.
- Marked lineage-specific divergence occurred within this conserved framework, with extensive neuronal specialization across vertebrate lineages.
- Regulatory shifts were associated with spatial reorganization and functional diversification of neuronal populations.
- Findings suggest a cerebellum-like architecture predates the jawed vertebrate cerebellum, revealing constraints on neural organization and cellular innovations driving evolutionary diversification.