Predictors of treatment response to mineralocorticoid receptor antagonists in primary aldosteronism: insights from the SPAIN-ALDO registry - PubMed
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- #primary aldosteronism
- #mineralocorticoid receptor antagonists
- #treatment response
- The study aimed to identify predictors of treatment response to mineralocorticoid receptor antagonists (MRA) in primary aldosteronism using data from the SPAIN-ALDO registry.
- Among 402 patients, 16.2% achieved complete clinical success, while 50.1% had complete biochemical response after at least 6 months of MRA therapy.
- Predictors of complete clinical response included female gender, lower BMI, fewer antihypertensive medications, and higher potassium levels.
- Predictors of complete biochemical response included lower baseline aldosterone, higher baseline renin, use of spironolactone over eplerenone, and higher MRA doses.
- The conclusion emphasized early diagnosis and optimized MRA titration, particularly with eplerenone, to improve outcomes in primary aldosteronism.