Ultra-sensitive detection of mutant KRAS in circulating tumor DNA predicts survival in resectable pancreatic adenocarcinoma - PubMed
3 hours ago
- #ultra-deep sequencing
- #KRAS mutation
- #pancreatic cancer prognosis
- The study focuses on using ultra-deep sequencing for detecting KRAS mutations in circulating tumor DNA (ctDNA) in patients with localized pancreatic adenocarcinoma.
- Baseline ctDNA from 45 patients was analyzed, with ultra-deep sequencing detecting mutations in 18 patients, a 46% increase over standard sequencing.
- Detection of KRAS mutations via ultra-deep sequencing was significantly associated with worse overall survival, showing better predictive power than standard methods and serum CA 19-9.
- The findings highlight the prognostic value of advanced liquid biopsy technology for stratifying patients and tailoring treatment decisions in resectable pancreatic cancer.