Outcomes of intravenous thrombolysis in patients with acute ischemic stroke and direct oral anticoagulant use within 1 day before stroke onset - PubMed
4 hours ago
- #Intravenous Thrombolysis
- #Acute Ischemic Stroke
- #Direct Oral Anticoagulants
- The study investigated outcomes of intravenous thrombolysis (IVT) in acute ischemic stroke patients who used direct oral anticoagulants (DOACs) within 1 day before stroke onset.
- Using TriNetX data from 2010–2024, researchers compared patients with recent DOAC use (n=1,183) to those without anticoagulant use (n=63,462), employing propensity score matching.
- Results showed the DOAC group had lower risks of intracranial hemorrhage and major bleeding within 2 days after IVT compared to the no-anticoagulant group.
- Mortality rates at 30 and 90 days were similar between groups, and apixaban, a specific DOAC, was associated with reduced intracranial hemorrhage and mortality risks in subgroup analysis.
- The study concluded that recent DOAC use does not increase bleeding or mortality risks in acute ischemic stroke patients receiving IVT.