Impact of a comprehensive healthy lifestyle and genetic risk on arrhythmia: insights from the UK biobank study - PubMed
4 hours ago
- #Arrhythmia
- #Genetic Risk
- #Healthy Lifestyle
- The study evaluated the impact of a healthy lifestyle and genetic risk on arrhythmia risk among UK Biobank participants, excluding those with baseline arrhythmias.
- A healthy lifestyle score (HLS) was created based on smoking, alcohol, diet, and physical activity, with higher scores linked to lower risks of overall arrhythmia and atrial fibrillation.
- Over a mean follow-up of 10.9 years, favorable lifestyle categories showed reduced risks for atrial fibrillation (HR 0.89), overall arrhythmia (HR 0.91), and bradyarrhythmia (HR 0.92) compared to unfavorable lifestyles.
- Genetic susceptibility was assessed using a polygenic risk score (PRS), with joint analyses indicating the lowest atrial fibrillation risk in those with both low genetic risk and favorable lifestyle.
- Sensitivity analyses, including competing risks, supported the lifestyle associations for atrial fibrillation and overall arrhythmia, while bradyarrhythmia associations were weaker and non-monotonic.
- The findings suggest that healthier lifestyles may modestly reduce arrhythmia risks, but causal inference requires confirmation through randomized lifestyle-intervention studies.