Pancreatic Cancer Early Detection Biomarkers for High-Risk Individuals: Insights From the PRECEDE Consortium - PubMed
3 hours ago
- #pancreatic cancer
- #early detection
- #biomarkers
- Pancreatic cancer (PDAC) is highly lethal due to late detection and limited treatment options.
- Early detection efforts focus on imaging and liquid biopsy biomarkers for high-risk individuals.
- Organ-specific fluid analysis, like cyst fluid, offers enhanced specificity in screening.
- Advances in radiomics, microbiome, and multi-omics are expanding early detection methods.
- Challenges include non-invasive diagnosis of precursor lesions and low biomarker levels in early stages.
- Multi-institutional initiatives like PRECEDE aim to validate biomarkers and improve clinical translation.