Galactosylated LNP-mediated hepatic Sam68 silencing improves glucose homeostasis in diabetes by suppressing gluconeogenesis - PubMed
3 days ago
- #Sam68 silencing
- #siRNA delivery
- #hepatic gluconeogenesis
- Sam68 overexpression in livers contributes to hyperglycemia in type 2 diabetes.
- Galactose-decorated lipid nanoparticles (LNP-Gal) effectively deliver siRNA to hepatocytes for Sam68 silencing.
- siSam68/LNP-Gal reduces hepatic gluconeogenesis and improves glucose control in diabetic mouse models.
- This approach shows potential as a safe and targeted siRNA therapy for type 2 diabetes.