Early timepoint 99mTc-DPD whole body scintigraphy and quantitative SPECT/CT imaging for diagnosis of cardiac ATTR amyloidosis - PubMed
4 hours ago
- #Diagnostic Imaging
- #Nuclear Cardiology
- #Cardiac Amyloidosis
- The study compares early (1 hour post-injection) 99mTc-DPD scintigraphy and SPECT/CT imaging to late (2.5-3 hours) imaging for diagnosing cardiac transthyretin amyloidosis (ATTR-CM).
- Early imaging demonstrated comparable diagnostic accuracy, sensitivity, and specificity to late imaging, with higher quantitative measures (HMR and SUVmax).
- Adoption of early imaging protocols could improve patient comfort and workflow efficiency while maintaining diagnostic performance.
- Visual evaluation using the Perugini score showed slightly lower inter-observer agreement in early imaging compared to late imaging.
- The findings were validated using an external cohort, confirming the reliability of early imaging for ATTR-CM diagnosis.