Inorganic nitrogen metabolic reprogramming of the gut microbiome drives fecal microbiota transplantation in ulcerative colitis - PubMed
5 hours ago
- #fecal microbiota transplantation
- #ulcerative colitis
- #gut microbiome
- Fecal microbiota transplantation (FMT) success in ulcerative colitis depends on donor microbiota engraftment.
- Inorganic nitrogen utilization capacity (IN-uc) is key for gut microbial assembly in high oxidative stress environments.
- Engineered probiotic-metabolite consortia (PM-mix14) increase IN-uc, reduce oxidative stress, and enhance donor microbe colonization.
- PM-mix14 improves microbial engraftment in mouse colitis models, leading to better anti-inflammatory responses and less colonic damage.
- Clinical data supports IN-uc as a predictor for UC remission after FMT.