Histologic signatures as predictors of intestinal barrier impairment in inflammatory bowel disease: integration with endoscopic and molecular markers - PubMed
4 hours ago
- #Intestinal Barrier
- #Histology
- #Inflammatory Bowel Disease
- Histologic signatures correlate with intestinal barrier impairment (BI) in IBD patients.
- Epithelial and lamina propria neutrophils correlate strongly with epithelial BI.
- Chronic inflammatory infiltrate correlates with vascular BI and PV-1 expression in Crohn's disease.
- Multimodal evaluation combining histology, advanced imaging, and molecular profiling improves outcome prediction.
- Patients with both barrier alterations and inflammatory infiltrate have higher adverse outcome rates.