Topical Mitomycin C Chemotherapy After Surgical Resection of Conjunctival Amelanotic Melanoma in a Dog - PubMed
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- #topical chemotherapy
- #mitomycin C
- #conjunctival melanoma
- Describes a case where adjuvant topical mitomycin C (MMC) was used after incomplete surgical resection of conjunctival amelanotic melanoma in a 15-year-old Shih Tzu.
- The tumor was confined to the conjunctiva without systemic metastases, and surgical debulking was performed due to owner refusal of exenteration.
- Histopathology confirmed malignant amelanotic melanoma with incomplete margins.
- Topical 0.04% MMC was applied four times daily for one month post-healing, leading to side effects like corneal epithelial defects and conjunctival hyperemia that resolved after discontinuation.
- Long-term follow-up noted reduced tear production managed with cyclosporine.
- No local tumor recurrence was observed during the 14-month follow-up period.
- Suggests topical MMC as a potential globe-preserving adjuvant treatment for incompletely excised conjunctival melanoma, though further studies on efficacy and safety are needed.