ACLY alleviates cerebral ischemia/reperfusion injury by reducing oxidative stress and enhancing mitochondrial function via histone acetylation - PubMed
4 hours ago
- #epigenetics
- #ACLY
- #ischemic stroke
- ACLY expression is upregulated during cerebral ischemia/reperfusion (I/R) injury in a mouse model.
- Inhibiting or knocking down ACLY worsens cerebral I/R injury in vivo and reduces neuronal cell viability in vitro.
- ACLY enhances histone acetylation via acetyl-CoA accumulation, improving mitochondrial function and reducing oxidative stress.
- The ACLY-mediated metabolic-epigenetic axis may be a therapeutic target for ischemic stroke.