Identification of characteristic hub genes in the immune-active phase of chronic hepatitis B - PubMed
3 hours ago
- #chronic hepatitis B
- #immune-active phase
- #SLC24A4
- Study focuses on the immune-active phase of chronic hepatitis B (CHB) to identify key hub genes involved in host-virus interactions.
- Integration of bioinformatics and machine learning identified four hub genes: CCR5, IL10RA, KCNA3, and SLC24A4, with SLC24A4 being a key regulator.
- SLC24A4 expression is elevated in peripheral classical monocytes during the IA phase and correlates with a pro-inflammatory microenvironment.
- In silico knockout suggests SLC24A4 may negatively regulate monocyte activation, potentially restraining excessive inflammation.
- Virtual screening predicts Rucaparib as a potential FDA-approved compound targeting SLC24A4 for immune modulation in CHB.