The E3 ubiquitin ligase Itch plays an essential role in kidney fibrosis by inhibiting Dvl2/GSK3β/β-catenin signaling pathway - PubMed
3 hours ago
- #Dvl2 signaling
- #kidney fibrosis
- #E3 ubiquitin ligase
- Itch, an E3 ubiquitin ligase, shows decreased expression in renal tubules of CKD patients and fibrotic mouse models (UUO and FA).
- Loss of Itch worsens kidney fibrosis and inflammation, while overexpression alleviates these effects in mice.
- Itch promotes K48-linked ubiquitination of Dvl2 at lysine 343, leading to its proteasomal degradation.
- Degradation of Dvl2 suppresses the GSK-3β/β-catenin signaling pathway, reducing fibrotic responses.
- Itch may serve as a therapeutic target to slow progression of fibrotic kidney disease.