Infection and increased risk of incident dementia: the role of biological aging - PubMed
3 hours ago
- #dementia
- #infection
- #biological aging
- Hospital-treated infectious diseases significantly increase dementia risk, with a hazard ratio of 2.39.
- Infections elevate the risk of all dementia subtypes, including Alzheimer’s disease, vascular dementia, and young-onset dementia, across various pathogens, severities, and body sites.
- Accelerated biological aging, measured by phenotypic age, strengthens the link between infection and dementia risk, showing a significant interaction effect (HR = 1.20).
- APOE ε4 carrier status influences both the infection-dementia relationship and the moderating role of accelerated aging, requiring consideration in prevention strategies.
- The findings suggest that infection prevention and anti-aging interventions could help reduce dementia risk.