Mitochondrial Alterations and CKD - PubMed
3 hours ago
- #Mitochondrial health
- #Therapeutic targets
- #CKD pathogenesis
- Mitochondrial alterations are central to the pathogenesis of chronic kidney disease (CKD), impacting energy metabolism, oxidative stress, and cellular responses.
- The review covers mitochondrial remodeling in diabetic and non-diabetic CKD, including bioenergetics, dynamics, redox balance, and biogenesis.
- Advanced assessment methods include high-resolution respirometry, metabolomics, transcriptomics, functional MRI, and PET radiotracers.
- Promising therapeutic agents include SGLT2 inhibitors, GLP-1 receptor agonists, nsMRAs, glucose-dependent insulinotropic polypeptide, glucagon receptor agonists, NAD+ boosters, and CoQ10 derivatives.
- Multi-omics integration and spatial profiling enable precision phenotyping and mitochondrial health scores for individualized CKD therapy.