Association of the CHG Index with the onset, progression, and prognosis of cardiovascular-kidney-metabolic syndrome: findings from two large prospective cohorts - PubMed
4 hours ago
- #risk prediction
- #cardiovascular-kidney-metabolic syndrome
- #CHG index
- The CHG index, reflecting cholesterol, HDL, and glucose levels, predicts increased risks of type 2 diabetes, cardiovascular disease, and chronic kidney disease in the general population.
- Higher CHG levels are linked to accelerated progression of cardiovascular-kidney-metabolic (CKM) syndrome stages, from early to advanced, in two large prospective cohorts.
- In patients with established coronary artery disease (CKM Stage 4), elevated CHG is associated with a higher risk of major adverse cardiovascular and cerebrovascular events (MACCE).
- Machine learning analysis indicates that the prognostic impact of CHG is especially strong in patients with low systemic inflammation and high HbA1c levels.
- The study supports the CHG index's utility for risk stratification and both primary and secondary prevention across the CKM syndrome continuum.