New Adjuvant Therapies for Obesity-Related Disorders Associated with Meta-Neuroinflammation - PubMed
2 hours ago
- #Obesity
- #Neuroinflammation
- #Chronic Pain
- Obesity is a chronic disease linked to painful conditions like osteoarthritis.
- Meta-neuroinflammation describes how systemic inflammation in obesity causes neuroinflammation, central sensitization, and chronic pain.
- Obesity-related meta-neuroinflammation involves mechanisms like adiposopathy, gut microbiota dysbiosis, and blood-brain barrier disruption.
- Targeted therapies include ultramicronized palmitoylethanolamide (um-PEA) for neuroprotection, anti-inflammatory, and pain relief.
- Comicronized PEA-rutin and hydroxytyrosol may restore gut health, aiding weight and mental disorders.
- Adelmidrol, a PEA congener, might reduce intra-articular meta-neuroinflammation in knee osteoarthritis.