Multi-tier signaling and chromatin remodeling coordinate microglia inflammatory states and activities associated with demyelination - PubMed
4 hours ago
- #microglia
- #epigenetics
- #demyelination
- The study identifies two dominant inflammatory microglia states in demyelination: Clec7a+CD229+CD11c- (proliferation-prone, high Fn1/Vegfa) and Clec7a+CD229+CD11c+ (tissue-remodeling/antigen presentation).
- Achieving these states involves genome-wide nucleosome remodeling driven by transcription factors like Pu.1, AP-1, C/ebp, Mef2, and Egr2.
- An H3K27me3-based gatekeeping mechanism controls key regulators, including Egr2, in microglial polarization.
- Trem2, Mef2a, and Egr2 are validated as relevant to the inflammatory microglial polarization process in demyelination.