Association analysis of short-chain fatty acid levels and intestinal mucosal healing in ulcerative colitis patients - PubMed
4 hours ago
- #ulcerative colitis
- #short-chain fatty acids
- #mucosal healing
- Ulcerative colitis (UC) patients have lower fecal short-chain fatty acids (SCFAs) than healthy controls.
- Butyrate levels are significantly higher in UC patients with mucosal healing compared to those without.
- Higher butyrate levels correlate with lower Mayo endoscopic scores and increased expression of related genes (SLC16A1, ACSM3, ACADS).
- Fecal butyrate independently predicts mucosal healing with an AUC of 0.847.
- A combined model of butyrate, C-reactive protein, and corticosteroid use improves predictive accuracy (AUC = 0.896).
- Fecal butyrate is proposed as a non-invasive biomarker for assessing UC mucosal healing to aid personalized treatment.